RSPO2 and ZNF837

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		RSPO2	ZNF837
Name		R-spondin 2	zinc finger protein 837
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface	Nucleus
	Molecular Function	Signaling Receptor Binding Protein Binding Heparin Binding BMP Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Canonical Wnt Signaling Pathway Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of FZD by ubiquitination	None
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464 ) Blond vs. brown/black hair color ( 30531825 ) Blood protein levels ( 30072576 ) BMI x environmental factors (excluding physical activity) interaction ( 33654129 ) Brain morphology (MOSTest) ( 32665545 ) Dupuytren's disease ( 21732829 28886342 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 28552196 ) Intake of total sugars ( 31005972 ) Macular thickness ( 30535121 ) Male-pattern baldness ( 28196072 29146897 ) Ossification of the posterior longitudinal ligament of the spine ( 25064007 )	No GWAS studies recorded
Interacting Genes		15 interacting genes: CATSPER1 CYSRT1 HOXA1 JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP12-3 PLEKHF2 SLC39A7 SUV39H1 ZNF330 ZNF837	77 interacting genes: BAHD1 CARD10 CATSPER1 CCDC125 CCDC136 CCNDBP1 CDC37 CHIC2 CLK2 CYSRT1 DHX57 DVL3 EFEMP2 EHMT2 FSD2 GOLGA6L9 GPATCH2L HOXA1 KHDRBS2 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-11 KRTAP4-12 KRTAP4-5 KRTAP5-9 MDFI MTUS2 MYO15B NBPF19 NOTCH2NLA PCSK5 PHF19 PPARD PPP1R37 PRPF31 RBMY1F RBMY1J RSPO2 SPRED2 SPRY1 TCEANC TNS2 TRIM41 TRMT2A UBE2I VWC2 ZBTB24 ZBTB48 ZBTB8A ZNF121 ZNF124 ZNF165 ZNF17 ZNF202 ZNF250 ZNF275 ZNF330 ZNF408 ZNF417 ZNF473 ZNF497 ZNF524 ZNF526 ZNF552 ZNF587 ZNF639 ZNF648 ZNF655 ZNF764 ZNF792 ZNF835 ZRANB1 ZSCAN21
Entrez ID		340419	116412
HPRD ID		17536	Not available
Ensembl ID		ENSG00000147655	ENSG00000152475
Uniprot IDs		B3KVP3 Q6UXX9	Q96EG3
PDB IDs		8XFP 8XFS 8XFT 8XUM 8Y69	Not available
GO Terms Enriched among Interactors		Keratin Filament Intermediate Filament Semicircular Canal Formation Skin Epidermis Development Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation	Zinc Ion Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Keratin Filament Intermediate Filament Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Primary Metabolic Process Regulation Of Gene Expression Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Hair Cycle Nucleus Negative Regulation Of Lens Fiber Cell Differentiation Regulation Of Macromolecule Metabolic Process Regulation Of Lens Fiber Cell Differentiation Identical Protein Binding