UBR1

Name	ubiquitin protein ligase E3 component n-recognin 1
Structure
Interactors	33 interactors: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 COXFA4L2 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PLIN2 PTPRS RGS4 SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways	Antigen processing: Ubiquitination & Proteasome degradation
Diseases	Johanson-Blizzard syndrome
GWAS	Appendicular lean mass ( 33097823 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) MGMT methylation in smokers ( 26183928 ) Triglycerides ( 25961943 )
Entrez ID	197131
HPRD ID	09342
Ensembl ID	ENSG00000159459
Uniprot IDs	Q8IWV7
PDB IDs	3NY1 5TDC
GO Terms Enriched among Interactors ?	Protein-N-terminal Asparagine Amidohydrolase Activity HULC Complex Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors