CSF3R

Name	colony stimulating factor 3 receptor
Structure
Novel Interactors	1 novel interactors: HPCA
Interactors	19 interactors: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2
GO Annotations	Cellular Component	Extracellular Region Lysosomal Membrane Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane Receptor Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Granulocyte Colony-stimulating Factor Binding
	Biological Process	Defense Response Cell Adhesion Signal Transduction Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Regulation Of Myeloid Cell Differentiation Amelogenesis
Pathways	Other interleukin signaling Transcriptional regulation of granulopoiesis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling
Drugs	Pegfilgrastim Filgrastim FavId Lenograstim Lipegfilgrastim Eflapegrastim
GWAS	Basophil count ( 32888494 ) Cerebrospinal fluid p-tau levels ( 29274321 ) Cerebrospinal fluid t-tau levels ( 29274321 ) Eosinophil percentage of white cells ( 32888494 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Iron status biomarkers (total iron binding capacity) ( 28334935 ) Iron status biomarkers (transferrin saturation) ( 28334935 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 27863252 29403010 32888494 )
Entrez ID	1441
HPRD ID	00737
Ensembl ID	ENSG00000119535
Uniprot IDs	Q99062
PDB IDs	2D9Q
GO Terms Enriched among Interactors ?	Intracellular Signal Transduction Phosphotyrosine Residue Binding Cytokine-mediated Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Immune Effector Process Negative Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell-cell Adhesion Interleukin-6-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Signaling Receptor Binding Regulation Of Defense Response Immune System Process Growth Hormone Receptor Signaling Pathway Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of MAPK Cascade Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Cell Population Proliferation Response To External Biotic Stimulus Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Cytosol Response To Other Organism Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signaling Leukocyte Migration Positive Regulation Of Cell Activation Regulation Of Cell Communication T Cell Costimulation Regulation Of Inflammatory Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Activation