CYCS and CYB5A |
cytochrome c, somatic |
cytochrome b5 type A (microsomal) |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
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- Metabolism of vitamins and cofactors
- Defective CD320 causes methylmalonic aciduria
- Defective GIF causes intrinsic factor deficiency
- Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
- Defective HLCS causes multiple carboxylase deficiency
- Defective MMAB causes methylmalonic aciduria type cblB
- Defective BTD causes biotidinase deficiency
- Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
- Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
- Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
- Vitamin C (ascorbate) metabolism
- Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
- Defective MMAA causes methylmalonic aciduria type cblA
- Defective CUBN causes hereditary megaloblastic anemia 1
- Defective AMN causes hereditary megaloblastic anemia 1
- Defective MUT causes methylmalonic aciduria mut type
- Metabolism of water-soluble vitamins and cofactors
- Defects in biotin (Btn) metabolism
- Defective TCN2 causes hereditary megaloblastic anemia
- Defects in cobalamin (B12) metabolism
- Defects in vitamin and cofactor metabolism
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- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
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- Heme
- Dimethyl Propionate Ester Heme
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MME and PIK3R1 |
membrane metallo-endopeptidase |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
- Peptide hormone metabolism
- Metabolism of Angiotensinogen to Angiotensins
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- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- GP1b-IX-V activation signalling
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
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- Candoxatril
- N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1\'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine
- Phosphoramidon
- N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine
- [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala
- 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM
- Thiorphan
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- Isoproterenol
- (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
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PDGFRB and PIK3R1 |
platelet-derived growth factor receptor, beta polypeptide |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- PIP3 activates AKT signaling
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Innate Immune System
- Signaling by PDGF
- Signalling by NGF
- DAP12 interactions
- GAB1 signalosome
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by FGFR
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
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- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- GP1b-IX-V activation signalling
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
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- Becaplermin
- Sorafenib
- Imatinib
- Dasatinib
- Sunitinib
- Pazopanib
- Regorafenib
|
- Isoproterenol
- (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
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CYCS and FDX1 |
cytochrome c, somatic |
ferredoxin 1 |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
|
- Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
- Metabolism of lipids and lipoproteins
- Pregnenolone biosynthesis
- Mitochondrial iron-sulfur cluster biogenesis
- Metabolic disorders of biological oxidation enzymes
- Phase 1 - Functionalization of compounds
- Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
- Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
- Electron transport from NADPH to Ferredoxin
- Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
- Cytochrome P450 - arranged by substrate type
- Endogenous sterols
- Biological oxidations
- Defective FMO3 causes Trimethylaminuria (TMAU)
- Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
- Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
- Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
- Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
- Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
- Defective CYP1B1 causes Glaucoma
- Metabolism of steroid hormones and vitamin D
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
- Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
- Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
- Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
- Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
- Defective MAOA causes Brunner syndrome (BRUNS)
- Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
- Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
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- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
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BCAT2 and APP |
branched chain amino-acid transaminase 2, mitochondrial |
amyloid beta (A4) precursor protein |
- Branched-chain amino acid catabolism
- Metabolism of amino acids and derivatives
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- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
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- Pyridoxal Phosphate
- L-Glutamic Acid
- L-Leucine
- L-Isoleucine
- Pyridoxamine-5\'-Phosphate
- N-[O-Phosphono-Pyridoxyl]-Isoleucine
- Alpha-ketoisovalerate
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GSTA1 and APP |
glutathione S-transferase alpha 1 |
amyloid beta (A4) precursor protein |
- Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
- Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
- Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
- Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
- Defective UGT1A4 causes hyperbilirubinemia
- Glutathione conjugation
- Metabolic disorders of biological oxidation enzymes
- Phase II conjugation
- Defective UGT1A1 causes hyperbilirubinemia
- Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
- Biological oxidations
- Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
- Defective GGT1 causes Glutathionuria (GLUTH)
- Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
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- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
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- Glutathione
- S-Hydroxycysteine
- 2-Hydroxyethyl Disulfide
- N-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine
- Glutathione Sulfonic Acid
- S-Benzyl-Glutathione
- S-Hexylglutathione
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GALE and APP |
UDP-galactose-4-epimerase |
amyloid beta (A4) precursor protein |
- Galactose catabolism
- Myoclonic epilepsy of Lafora
- Glycogen storage diseases
- Metabolism of carbohydrates
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- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
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- Glucose-Uridine-C1,5\'-Diphosphate
- Nicotinamide-Adenine-Dinucleotide
- Uridine-Diphosphate-N-Acetylgalactosamine
- Tetramethylammonium Ion
- Uridine-Diphosphate-N-Acetylglucosamine
- Uridine Diphosphate Galactose
- Uridine-5\'-Monophosphate Glucopyranosyl-Monophosphateester
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CDK5 and APP |
cyclin-dependent kinase 5 |
amyloid beta (A4) precursor protein |
- Signaling by GPCR
- Axon guidance
- Semaphorin interactions
- Opioid Signalling
- DARPP-32 events
- CRMPs in Sema3A signaling
- Factors involved in megakaryocyte development and platelet production
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- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
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- Indirubin-3\'-Monoxime
- Olomoucine
- Hymenialdisine
- SU9516
- Flavopiridol
- Alsterpaullone
- 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
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TUBB and APP |
tubulin, beta class I |
amyloid beta (A4) precursor protein |
- Organelle biogenesis and maintenance
- Loss of proteins required for interphase microtubule organization from the centrosome
- Loss of Nlp from mitotic centrosomes
- G2/M Transition
- Assembly of the primary cilium
- Centrosome maturation
- Regulation of PLK1 Activity at G2/M Transition
- Mitotic G2-G2/M phases
- Anchoring of the basal body to the plasma membrane
- Recruitment of mitotic centrosome proteins and complexes
- Cell Cycle, Mitotic
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- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
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- Vinorelbine
- Vincristine
- Vinblastine
- Podofilox
- Colchicine
- Epothilone D
- Epothilone B
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TOP1 and APP |
topoisomerase (DNA) I |
amyloid beta (A4) precursor protein |
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- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
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- Irinotecan
- Topotecan
- Camptothecin
- Lucanthone
- Sodium stibogluconate
- 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM
- 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
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CYCS and BCL2L1 |
cytochrome c, somatic |
BCL2-like 1 |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
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- Inflammasomes
- The NLRP1 inflammasome
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Programmed Cell Death
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Innate Immune System
- Intrinsic Pathway for Apoptosis
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- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
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CYCS and CASP9 |
cytochrome c, somatic |
caspase 9, apoptosis-related cysteine peptidase |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
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- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- PIP3 activates AKT signaling
- SMAC binds to IAPs
- SMAC-mediated dissociation of IAP:caspase complexes
- Cytochrome c-mediated apoptotic response
- SMAC-mediated apoptotic response
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Role of DCC in regulating apoptosis
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- PI3K/AKT activation
- PI-3K cascade
- Apoptotic factor-mediated response
- NOD1/2 Signaling Pathway
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Programmed Cell Death
- Innate Immune System
- Intrinsic Pathway for Apoptosis
- Signaling by PDGF
- DAP12 interactions
- Signalling by NGF
- GAB1 signalosome
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- Signaling by FGFR
- Signaling by ERBB2
- Signaling by EGFR
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Extrinsic Pathway
- Adaptive Immune System
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- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
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CDK5 and PSEN1 |
cyclin-dependent kinase 5 |
presenilin 1 |
- Signaling by GPCR
- Axon guidance
- Semaphorin interactions
- Opioid Signalling
- DARPP-32 events
- CRMPs in Sema3A signaling
- Factors involved in megakaryocyte development and platelet production
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- Degradation of the extracellular matrix
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- Indirubin-3\'-Monoxime
- Olomoucine
- Hymenialdisine
- SU9516
- Flavopiridol
- Alsterpaullone
- 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
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CYCS and CYC1 |
cytochrome c, somatic |
cytochrome c-1 |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
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- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Respiratory electron transport
- Mitochondrial protein import
- The citric acid (TCA) cycle and respiratory electron transport
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- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
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CYCS and HSPA8 |
cytochrome c, somatic |
heat shock 70kDa protein 8 |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
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- Processing of Capped Intron-Containing Pre-mRNA
- mRNA Splicing
- Regulation of mRNA stability by proteins that bind AU-rich elements
- Axon guidance
- Golgi Associated Vesicle Biogenesis
- Attenuation phase
- mRNA Splicing - Major Pathway
- L1CAM interactions
- Regulation of HSF1-mediated heat shock response
- Cellular response to heat stress
- AUF1 (hnRNP D0) destabilizes mRNA
- GABA synthesis, release, reuptake and degradation
- Clathrin derived vesicle budding
- Lysosome Vesicle Biogenesis
- HSF1-dependent transactivation
- Neurotransmitter Release Cycle
- CHL1 interactions
- trans-Golgi Network Vesicle Budding
- Transmission across Chemical Synapses
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- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
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CYCS and HSPB1 |
cytochrome c, somatic |
heat shock 27kDa protein 1 |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
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- Regulation of mRNA stability by proteins that bind AU-rich elements
- Signaling by VEGF
- AUF1 (hnRNP D0) destabilizes mRNA
- VEGFA-VEGFR2 Pathway
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- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
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CYCS and SAFB |
cytochrome c, somatic |
scaffold attachment factor B |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
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- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
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CYCS and SNCA |
cytochrome c, somatic |
synuclein, alpha (non A4 component of amyloid precursor) |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
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- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
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CYCS and VDAC2 |
cytochrome c, somatic |
voltage-dependent anion channel 2 |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
|
|
- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
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CYCS and RNF7 |
cytochrome c, somatic |
ring finger protein 7 |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
|
|
- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
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