AKT1 and GAB2 |
v-akt murine thymoma viral oncogene homolog 1 |
GRB2-associated binding protein 2 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- Signaling by Wnt
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- Regulation of mRNA stability by proteins that bind AU-rich elements
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- Translocation of GLUT4 to the plasma membrane
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- Metabolism of nitric oxide
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signalling by NGF
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Integrin alphaIIb beta3 signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- eNOS activation
- TCF dependent signaling in response to WNT
- KSRP destabilizes mRNA
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
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- Signaling by GPCR
- Signaling by FGFR in disease
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- Role of LAT2/NTAL/LAB on calcium mobilization
- Signaling by SCF-KIT
- Signaling by Interleukins
- GPCR downstream signaling
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Signaling by FGFR1 mutants
- Interleukin receptor SHC signaling
- Fc epsilon receptor (FCERI) signaling
- Signaling by FGFR mutants
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Signaling by FGFR1 fusion mutants
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Innate Immune System
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- Adenosine triphosphate
- Arsenic trioxide
- Inositol 1,3,4,5-Tetrakisphosphate
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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CCBL1 and APP |
cysteine conjugate-beta lyase, cytoplasmic |
amyloid beta (A4) precursor protein |
- Phenylalanine and tyrosine catabolism
- Abnormal metabolism in phenylketonuria
- Amino acid synthesis and interconversion (transamination)
- Tryptophan catabolism
- Metabolism of amino acids and derivatives
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- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
|
- Pyridoxal Phosphate
- Pyridoxamine-5\'-Phosphate
- D-Phenylalanine
- N\'-Pyridoxyl-Lysine-5\'-Monophosphate
- 1H-INDOL-3-YLACETIC ACID
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GAPDHS and APP |
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic |
amyloid beta (A4) precursor protein |
- Gluconeogenesis
- Glucose metabolism
- Myoclonic epilepsy of Lafora
- Glycogen storage diseases
- Glycolysis
- Metabolism of carbohydrates
|
- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
|
- NADH
- Nicotinamide-Adenine-Dinucleotide
- 6-(1,1-Dimethylallyl)-2-(1-Hydroxy-1-Methylethyl)-2,3-Dihydro-7h-Furo[3,2-G]Chromen-7-One
- N-Naphthalen-1-Ylmethyl-2\'-[3,5-Dimethoxybenzamido]-2\'-Deoxy-Adenosine
- N-1,2,3,4-Tetrahydronaphth-1-Yl-2\'-[3,5-Dimethoxybenzamido]-2\'-Deoxy-Adenosine
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GAPDH and APP |
glyceraldehyde-3-phosphate dehydrogenase |
amyloid beta (A4) precursor protein |
- Gluconeogenesis
- Glucose metabolism
- Myoclonic epilepsy of Lafora
- Glycogen storage diseases
- Glycolysis
- Metabolism of carbohydrates
|
- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
|
- NADH
- Nicotinamide-Adenine-Dinucleotide
- Adenosine-5-Diphosphoribose
- Thionicotinamide-Adenine-Dinucleotide
- 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
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PFKFB1 and APP |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 |
amyloid beta (A4) precursor protein |
- PP2A-mediated dephosphorylation of key metabolic factors
- Gluconeogenesis
- Glucose metabolism
- Integration of energy metabolism
- Myoclonic epilepsy of Lafora
- Glycogen storage diseases
- PKA-mediated phosphorylation of key metabolic factors
- Glycolysis
- Metabolism of carbohydrates
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- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
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- D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate
- 3-Phosphoglycerol
- Phosphothiophosphoric Acid-Adenylate Ester
- Guanosine-5\'-Triphosphate
- Fructose-6-Phosphate
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PPIA and APP |
peptidylprolyl isomerase A (cyclophilin A) |
amyloid beta (A4) precursor protein |
- HIV Infection
- Host Interactions of HIV factors
- Integration of provirus
- Platelet degranulation
- Basigin interactions
- Late Phase of HIV Life Cycle
- Cell surface interactions at the vascular wall
- Uncoating of the HIV Virion
- Early Phase of HIV Life Cycle
- Reverse Transcription of HIV RNA
- Assembly Of The HIV Virion
- HIV Life Cycle
- Budding and maturation of HIV virion
- Response to elevated platelet cytosolic Ca2+
- Minus-strand DNA synthesis
- Platelet activation, signaling and aggregation
- Binding and entry of HIV virion
- Plus-strand DNA synthesis
- APOBEC3G mediated resistance to HIV-1 infection
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- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
|
- Cyclosporine
- L-Proline
- (3r)-1-Acetyl-3-Methylpiperidine
- Ethyl Oxo(Piperidin-1-Yl)Acetate
- (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl-
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GAPDH and CAMK4 |
glyceraldehyde-3-phosphate dehydrogenase |
calcium/calmodulin-dependent protein kinase IV |
- Gluconeogenesis
- Glucose metabolism
- Myoclonic epilepsy of Lafora
- Glycogen storage diseases
- Glycolysis
- Metabolism of carbohydrates
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- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Organelle biogenesis and maintenance
- Signaling by FGFR in disease
- Phospholipase C-mediated cascade
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- DAG and IP3 signaling
- CaM pathway
- DAP12 signaling
- Downstream signaling of activated FGFR
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Post NMDA receptor activation events
- Innate Immune System
- Signaling by PDGF
- Calmodulin induced events
- Signalling by NGF
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- PLC beta mediated events
- Opioid Signalling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- EGFR interacts with phospholipase C-gamma
- Mitochondrial biogenesis
- Signaling by ERBB2
- CaMK IV-mediated phosphorylation of CREB
- Signaling by EGFR
- Activation of CaMK IV
- CREB phosphorylation through the activation of CaMKK
- Downstream signal transduction
- Calmodulin induced events
- PLC-gamma1 signalling
- Signaling by EGFR in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Transmission across Chemical Synapses
|
- NADH
- Nicotinamide-Adenine-Dinucleotide
- Adenosine-5-Diphosphoribose
- Thionicotinamide-Adenine-Dinucleotide
- 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
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CBS and PSMA1 |
cystathionine-beta-synthase |
proteasome (prosome, macropain) subunit, alpha type, 1 |
- Sulfur amino acid metabolism
- Metabolism of amino acids and derivatives
- Cysteine formation from homocysteine
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- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- T41 mutants of beta-catenin aren't phosphorylated
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- Stabilization of p53
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- DNA Replication Pre-Initiation
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Autodegradation of the E3 ubiquitin ligase COP1
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Adaptive Immune System
- CDK-mediated phosphorylation and removal of Cdc6
- Hedgehog ligand biogenesis
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Separation of Sister Chromatids
- HIV Infection
- Ubiquitin-dependent degradation of Cyclin D
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Autodegradation of Cdh1 by Cdh1:APC/C
- p53-Dependent G1 DNA Damage Response
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- p53-Independent DNA Damage Response
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Vpu mediated degradation of CD4
- Synthesis of DNA
- M/G1 Transition
- Ubiquitin-dependent degradation of Cyclin D1
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Signaling by Hedgehog
- Regulation of mitotic cell cycle
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- p53-Dependent G1/S DNA damage checkpoint
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- CDK-mediated phosphorylation and removal of Cdc6
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- truncations of AMER1 destabilize the destruction complex
- Processing-defective Hh variants abrogate ligand secretion
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- Mitotic Metaphase and Anaphase
- Regulation of ornithine decarboxylase (ODC)
- Antigen processing: Ubiquitination & Proteasome degradation
- Orc1 removal from chromatin
- Mitotic Anaphase
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Metabolism of amino acids and derivatives
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- Regulation of DNA replication
- Cell Cycle, Mitotic
- beta-catenin independent WNT signaling
- Orc1 removal from chromatin
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Cross-presentation of soluble exogenous antigens (endosomes)
- Antigen processing-Cross presentation
- CDT1 association with the CDC6:ORC:origin complex
- ER-Phagosome pathway
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- Pyridoxal Phosphate
- S-Adenosylmethionine
- L-Serine
- L-Cysteine
- Heme
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GRIN3B and DLG4 |
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B |
discs, large homolog 4 (Drosophila) |
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- Axon guidance
- L1CAM interactions
- Activation of Kainate Receptors upon glutamate binding
- CREB phosphorylation through the activation of Ras
- Trafficking of AMPA receptors
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- NrCAM interactions
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
- Activation of Ca-permeable Kainate Receptor
- Unblocking of NMDA receptor, glutamate binding and activation
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
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- L-Glutamic Acid
- Glycine
- Halothane
- Orphenadrine
- Tenocyclidine
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GAPDH and PSEN1 |
glyceraldehyde-3-phosphate dehydrogenase |
presenilin 1 |
- Gluconeogenesis
- Glucose metabolism
- Myoclonic epilepsy of Lafora
- Glycogen storage diseases
- Glycolysis
- Metabolism of carbohydrates
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- Degradation of the extracellular matrix
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- NADH
- Nicotinamide-Adenine-Dinucleotide
- Adenosine-5-Diphosphoribose
- Thionicotinamide-Adenine-Dinucleotide
- 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
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LRP2 and APOE |
low density lipoprotein receptor-related protein 2 |
apolipoprotein E |
- Metabolism of lipids and lipoproteins
- Visual phototransduction
- Diseases associated with visual transduction
- Metabolism of steroid hormones and vitamin D
- Vitamin D (calciferol) metabolism
- Retinoid metabolism and transport
|
- Lipoprotein metabolism
- Metabolism of lipids and lipoproteins
- Chylomicron-mediated lipid transport
- Lipid digestion, mobilization, and transport
- Diseases associated with visual transduction
- HDL-mediated lipid transport
- Visual phototransduction
- Scavenging by Class A Receptors
- Retinoid metabolism and transport
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- Urokinase
- Insulin Regular
- Insulin, porcine
- Gentamicin
|
- Human Serum Albumin
- Serum albumin iodonated
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CSF1R and PIK3R1 |
colony stimulating factor 1 receptor |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
|
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- GP1b-IX-V activation signalling
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
|
- Imatinib
- Sunitinib
- 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE
- 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE
|
- Isoproterenol
- (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
|
|
|
EPOR and PIK3R1 |
erythropoietin receptor |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
|
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- GP1b-IX-V activation signalling
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
|
- Darbepoetin alfa
- Epoetin alfa
- 3,5 DIBROMOTYROSINE
- Peginesatide
|
- Isoproterenol
- (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
|
|
|
HCK and PIK3R1 |
HCK proto-oncogene, Src family tyrosine kinase |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
- HIV Infection
- Host Interactions of HIV factors
- Cytokine Signaling in Immune system
- The role of Nef in HIV-1 replication and disease pathogenesis
- Nef and signal transduction
- Signaling by Interleukins
- Regulation of signaling by CBL
- Fcgamma receptor (FCGR) dependent phagocytosis
- Interleukin-3, 5 and GM-CSF signaling
- FCGR activation
- Innate Immune System
|
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- GP1b-IX-V activation signalling
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
|
- 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
- Phosphonotyrosine
- Quercetin
- Bosutinib
|
- Isoproterenol
- (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
|
|
|
IL2RB and PIK3R1 |
interleukin 2 receptor, beta |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- Signaling by Interleukins
- GPCR downstream signaling
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
|
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- GP1b-IX-V activation signalling
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
|
- Denileukin diftitox
- Aldesleukin
- Basiliximab
- Daclizumab
|
- Isoproterenol
- (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
|
|
|
ADH5 and APP |
alcohol dehydrogenase 5 (class III), chi polypeptide |
amyloid beta (A4) precursor protein |
|
- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
|
- NADH
- Nicotinamide-Adenine-Dinucleotide
- 12-Hydroxydodecanoic Acid
- S-Hydroxymethyl Glutathione
|
|
|
|
AKT2 and APP |
v-akt murine thymoma viral oncogene homolog 2 |
amyloid beta (A4) precursor protein |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- mTOR signalling
- Signaling by Wnt
- Activation of PKB
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- PDE3B signalling
- PKB-mediated events
- PI3K Cascade
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- PDE3B signalling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Inhibition of TSC complex formation by PKB
- Activation of PKB
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- mTOR signalling
- Translocation of GLUT4 to the plasma membrane
- IGF1R signaling cascade
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- Intrinsic Pathway for Apoptosis
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Insulin receptor signalling cascade
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Inhibition of TSC complex formation by PKB
- Signaling by FGFR
- IRS-mediated signalling
- TCF dependent signaling in response to WNT
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
- PKB-mediated events
- PI3K Cascade
|
- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
|
- N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
- 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
- ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
- (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
|
|
|
|
APRT and APP |
adenine phosphoribosyltransferase |
amyloid beta (A4) precursor protein |
- Purine metabolism
- Metabolism of nucleotides
- Purine salvage
|
- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
|
- Adenine
- Alpha-Phosphoribosylpyrophosphoric Acid
- 9-Deazaadenine
- Citric Acid
|
|
|
|
ASS1 and APP |
argininosuccinate synthase 1 |
amyloid beta (A4) precursor protein |
- Urea cycle
- Metabolism of amino acids and derivatives
|
- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
|
- L-Arginine
- L-Aspartic Acid
- L-Citrulline
- Adenosine triphosphate
|
|
|
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EIF4E and APP |
eukaryotic translation initiation factor 4E |
amyloid beta (A4) precursor protein |
- Translation initiation complex formation
- IRS-mediated signalling
- mTOR signalling
- Transport of the SLBP independent Mature mRNA
- mTOR signalling
- mTORC1-mediated signalling
- IGF1R signaling cascade
- Deadenylation-dependent mRNA decay
- IRS-related events triggered by IGF1R
- Eukaryotic Translation Initiation
- Release of eIF4E
- Transport of Mature Transcript to Cytoplasm
- Cap-dependent Translation Initiation
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
- Transport of Mature mRNA Derived from an Intronless Transcript
- Processing of Capped Intron-Containing Pre-mRNA
- Transport of the SLBP Dependant Mature mRNA
- Insulin receptor signalling cascade
- Deadenylation of mRNA
- Translation
- Transport of Mature mRNA derived from an Intron-Containing Transcript
- ISG15 antiviral mechanism
- Transport of Mature mRNAs Derived from Intronless Transcripts
- Interferon Signaling
- Cytokine Signaling in Immune system
- IRS-related events
- Release of eIF4E
- L13a-mediated translational silencing of Ceruloplasmin expression
- Antiviral mechanism by IFN-stimulated genes
- mTORC1-mediated signalling
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
- PKB-mediated events
- PI3K Cascade
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- Signaling by GPCR
- Platelet degranulation
- Metabolic disorders of biological oxidation enzymes
- RIP-mediated NFkB activation via ZBP1
- Formyl peptide receptors bind formyl peptides and many other ligands
- Amyloids
- Toll Like Receptor TLR1:TLR2 Cascade
- Peptide ligand-binding receptors
- Toll Like Receptor 5 (TLR5) Cascade
- The NLRP3 inflammasome
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- G alpha (i) signalling events
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- G alpha (q) signalling events
- GPCR downstream signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Platelet activation, signaling and aggregation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- ECM proteoglycans
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Advanced glycosylation endproduct receptor signaling
- Innate Immune System
- Inflammasomes
- Cytosolic sensors of pathogen-associated DNA
- MyD88-independent cascade
- GPCR ligand binding
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- TRAF6 mediated NF-kB activation
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- 7-Methyl-Gpppa
- 7n-Methyl-8-Hydroguanosine-5\'-Diphosphate
- 7-Methyl-Guanosine-5\'-Triphosphate
- 2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL
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