CCS and APBA1

Number of citations of the paper that reports this interaction (PubMedID 11115513)
0

Data Source:
HPRD (in vivo, in vitro)

		CCS	APBA1
Description		copper chaperone for superoxide dismutase	amyloid beta precursor protein binding family A member 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Membrane Dendritic Spine Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Copper Ion Binding Protein Binding Protein-disulfide Reductase Activity Superoxide Dismutase Copper Chaperone Activity Cadherin Binding Metal Ion Binding	Amyloid-beta Binding Protein Binding
	Biological Process	Superoxide Metabolic Process Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Protein Maturation	In Utero Embryonic Development Intracellular Protein Transport Cell Adhesion Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Axo-dendritic Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Protein Transport Multicellular Organism Growth Establishment Of Localization In Cell Protein-containing Complex Assembly Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Bipolar disorder ( 21926972)	Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: APBA1 SOD1 YWHAG	18 interacting genes: APP ARF3 ARF4 CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1 TJAP1
Entrez ID		9973	320
HPRD ID		04841	03879
Ensembl ID		ENSG00000173992	ENSG00000107282
Uniprot IDs		O14618	Q02410
PDB IDs		1DO5 2CRL 2RSQ 6FN8 6FOL 6FON 6FP6	1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N
Enriched GO Terms of Interacting Partners?		Locomotory Behavior Microtubule-based Transport Transport Along Microtubule Axo-dendritic Transport Cytoskeleton-dependent Intracellular Transport Response To Carbon Monoxide Response To Antipsychotic Drug Action Potential Initiation Protein Kinase C Inhibitor Activity Gamma-aminobutyric Acid Transport Gamma-aminobutyric Acid Secretion Microtubule-based Movement Glutamate Secretion Modulation Of Chemical Synaptic Transmission Reactive Oxygen Species Biosynthetic Process Response To Potassium Ion Myelin Maintenance Retrograde Axonal Transport Relaxation Of Muscle Cellular Response To ATP Neurofilament Cytoskeleton Organization Cellular Response To Cadmium Ion Regulation Of Superoxide Anion Generation Cellular Response To Potassium Ion Response To Nutrient Levels Ectopic Germ Cell Programmed Cell Death Hydrogen Peroxide Biosynthetic Process Negative Regulation Of Muscle Contraction Dense Core Granule Removal Of Superoxide Radicals Positive Regulation Of Superoxide Anion Generation Regulation Of Catalytic Activity Response To Superoxide Response To Oxygen Radical Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of T Cell Activation Superoxide Dismutase Activity Protein Phosphatase 2B Binding Auditory Receptor Cell Stereocilium Organization Relaxation Of Smooth Muscle Relaxation Of Vascular Associated Smooth Muscle Retina Homeostasis Mitochondrial Matrix Negative Regulation Of Smooth Muscle Contraction Peripheral Nervous System Myelin Maintenance Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Insulin-like Growth Factor Receptor Binding	Modulation Of Chemical Synaptic Transmission Plasma Membrane Establishment Of Localization In Cell Regulation Of Calcium Ion-dependent Exocytosis Synapse Regulation Of Regulated Secretory Pathway Presynaptic Membrane Positive Regulation Of Synaptic Transmission Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Vesicle-mediated Transport Positive Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Establishment Of Protein Localization Regulation Of Neurotransmitter Secretion Intracellular Protein Localization Neurotransmitter Transport Positive Regulation Of Excitatory Postsynaptic Potential Protein Transport Calcium-ion Regulated Exocytosis Regulation Of Synaptic Transmission, GABAergic Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Cellular Localization Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Vesicle-mediated Transport Neurotransmitter Secretion Regulation Of Transport Regulation Of Synapse Organization Intracellular Transport Chemical Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Cell Adhesion Regulation Of System Process Glutamatergic Synapse Positive Regulation Of Regulated Secretory Pathway Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Trans-synaptic Signaling Signal Release Synaptic Signaling Regulation Of Secretion Response To Amyloid-beta Positive Regulation Of ERK1 And ERK2 Cascade Secretion By Cell Exocytosis Regulation Of Synaptic Vesicle Priming Regulation Of Synaptic Transmission, Glutamatergic SNARE Complex Assembly Regulation Of Amine Transport
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