CCS and SOD1

Number of citations of the paper that reports this interaction (PubMedID 9726962)
0

Data Source:
HPRD (in vitro, in vivo)

		CCS	SOD1
Description		copper chaperone for superoxide dismutase	superoxide dismutase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Lysosome Peroxisome Cytosol Plasma Membrane Secretory Granule Dense Core Granule Cytoplasmic Vesicle Dendrite Cytoplasm Protein-containing Complex Neuronal Cell Body Extracellular Exosome Axon Cytoplasm
	Molecular Function	Copper Ion Binding Protein Binding Protein-disulfide Reductase Activity Superoxide Dismutase Copper Chaperone Activity Cadherin Binding Metal Ion Binding	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Zinc Ion Binding Antioxidant Activity Oxidoreductase Activity Enzyme Binding Protein Phosphatase 2B Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding
	Biological Process	Superoxide Metabolic Process Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Protein Maturation	Response To Reactive Oxygen Species Response To Superoxide Ovarian Follicle Development Positive Regulation Of Cytokine Production Placenta Development Retina Homeostasis Response To Amphetamine Myeloid Cell Homeostasis Glutathione Metabolic Process Superoxide Metabolic Process Intracellular Iron Ion Homeostasis Apoptotic Process Response To Oxidative Stress Spermatogenesis Embryo Implantation Sensory Perception Of Sound Locomotory Behavior Anterograde Axonal Transport Retrograde Axonal Transport Regulation Of Blood Pressure Determination Of Adult Lifespan Response To Heat Response To Xenobiotic Stimulus Gene Expression Transmission Of Nerve Impulse Neuronal Action Potential Removal Of Superoxide Radicals Response To Nutrient Levels Peripheral Nervous System Myelin Maintenance Positive Regulation Of Superoxide Anion Generation Regulation Of T Cell Differentiation In Thymus Response To Carbon Monoxide Cellular Response To Oxidative Stress Ectopic Germ Cell Programmed Cell Death Cellular Response To Potassium Ion Regulation Of Multicellular Organism Growth Response To Hydrogen Peroxide Superoxide Anion Generation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Regulation Of Organ Growth Response To Copper Ion Muscle Cell Cellular Homeostasis Thymus Development Response To Axon Injury Hydrogen Peroxide Biosynthetic Process Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Negative Regulation Of Developmental Process Regulation Of Mitochondrial Membrane Potential Heart Contraction Neurofilament Cytoskeleton Organization Relaxation Of Vascular Associated Smooth Muscle Auditory Receptor Cell Stereocilium Organization Cellular Response To Cadmium Ion Cellular Response To ATP Reactive Oxygen Species Metabolic Process Response To Antipsychotic Drug Action Potential Initiation Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reproductive Process
Pathways		Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species	Platelet degranulation Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Dopamine Isoprenaline Zinc 5-fluorouridine S-oxy-L-cysteine Arimoclomol Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Bipolar disorder ( 21926972)	Amyotrophic lateral sclerosis ( 20801718)
Interacting Genes		3 interacting genes: APBA1 SOD1 YWHAG	18 interacting genes: AMFR BCL2 CCS COMMD1 CRYAB DNAJB1 FNDC3B HOXB2 KARS1 MARCHF5 MYCBP2 PARK7 PAX6 PPP3CA RANBP9 RNF19A SMAD2 UBE3A
Entrez ID		9973	6647
HPRD ID		04841	00937
Ensembl ID		ENSG00000173992	ENSG00000142168
Uniprot IDs		O14618	P00441 V9HWC9
PDB IDs		1DO5 2CRL 2RSQ 6FN8 6FOL 6FON 6FP6	1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2MP3 2NAM 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ 3ECU 3ECV 3ECW 3GQF 3GTV 3GZO 3GZP 3GZQ 3H2P 3H2Q 3HFF 3K91 3KH3 3KH4 3LTV 3QQD 3RE0 3T5W 4A7G 4A7Q 4A7S 4A7T 4A7U 4A7V 4B3E 4BCY 4BCZ 4BD4 4FF9 4MCM 4MCN 4NIN 4NIO 4NIP 4OH2 4XCR 5DLI 5IIW 5J07 5J0C 5J0F 5J0G 5K02 5O3Y 5O40 5U9M 5WMJ 5WOR 5YTO 5YTU 5YUL 6A9O 6B79 6DTK 6FFK 6FLH 6FOI 6FOL 6FON 6FP6 6SPA 6SPH 6SPI 6SPJ 6SPK 6Z3V 6Z4G 6Z4H 6Z4I 6Z4J 6Z4K 6Z4L 6Z4M 6Z4O 7CJV 7CJW 7FB6 7FB9 7NXX 7T8E 7T8F 7T8G 7T8H 7VZF 7XX3 8CCX 8GSQ 8IHU 8IHV 8K33 8K3A 8K3L 8Q6M 8YAT 8YD3 9IYK 9JBO 9JBP
Enriched GO Terms of Interacting Partners?		Locomotory Behavior Microtubule-based Transport Transport Along Microtubule Axo-dendritic Transport Cytoskeleton-dependent Intracellular Transport Response To Carbon Monoxide Response To Antipsychotic Drug Action Potential Initiation Protein Kinase C Inhibitor Activity Gamma-aminobutyric Acid Transport Gamma-aminobutyric Acid Secretion Microtubule-based Movement Glutamate Secretion Modulation Of Chemical Synaptic Transmission Reactive Oxygen Species Biosynthetic Process Response To Potassium Ion Myelin Maintenance Retrograde Axonal Transport Relaxation Of Muscle Cellular Response To ATP Neurofilament Cytoskeleton Organization Cellular Response To Cadmium Ion Regulation Of Superoxide Anion Generation Cellular Response To Potassium Ion Response To Nutrient Levels Ectopic Germ Cell Programmed Cell Death Hydrogen Peroxide Biosynthetic Process Negative Regulation Of Muscle Contraction Dense Core Granule Removal Of Superoxide Radicals Positive Regulation Of Superoxide Anion Generation Regulation Of Catalytic Activity Response To Superoxide Response To Oxygen Radical Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of T Cell Activation Superoxide Dismutase Activity Protein Phosphatase 2B Binding Auditory Receptor Cell Stereocilium Organization Relaxation Of Smooth Muscle Relaxation Of Vascular Associated Smooth Muscle Retina Homeostasis Mitochondrial Matrix Negative Regulation Of Smooth Muscle Contraction Peripheral Nervous System Myelin Maintenance Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Insulin-like Growth Factor Receptor Binding	Protein K48-linked Ubiquitination Superoxide Dismutase Copper Chaperone Activity Cytosol Protein Polyubiquitination Post-translational Protein Modification Organ Growth Copper Ion Binding Ubiquitin Protein Ligase Activity Intracellular Signal Transduction Protein Autoubiquitination Identical Protein Binding Protein Ubiquitination Cytoplasm Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Co-SMAD Binding Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Protein Metabolic Process Negative Regulation Of Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Dorsal/ventral Axis Specification Removal Of Superoxide Radicals Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Post-translational Protein Modification Protein K27-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Reactive Oxygen Species Metabolic Process Ubiquitin-specific Protease Binding Response To Hydrogen Peroxide Negative Regulation Of Monoatomic Ion Transport Neuron Projection Morphogenesis Ubiquitin Ligase Complex Cell Projection Morphogenesis Mitochondrion Positive Regulation Of Protein Ubiquitination Protein Modification Process Androgen Receptor Signaling Pathway Regulation Of Cellular Response To Stress Negative Regulation Of Transmembrane Transport Intracellular Signaling Cassette Embryonic Organ Morphogenesis R-SMAD Binding Positive Regulation Of Post-translational Protein Modification Skeletal Muscle Fiber Development Gland Morphogenesis Response To Ionizing Radiation
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