MED12 and MED29

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (pull down, affinity chromatography technology, biochemical)

		MED12	MED29
Gene Name		mediator complex subunit 12	mediator complex subunit 29
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Centrosome Membrane Mediator Complex	Nucleoplasm Mediator Complex
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	Protein Binding
	Biological Process	Neural Tube Closure Transcription Initiation From RNA Polymerase II Promoter Heart Development Gene Expression Oligodendrocyte Development Schwann Cell Development Stem Cell Maintenance Negative Regulation Of Wnt Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Axis Elongation Involved In Somitogenesis	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CDK8 ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED29 MED8 MED9 MYC NANOG PPARGC1A SOX9 SREBF1 VDR	9 interactors: MED1 MED12 MED13 MED14 MED17 MED20 MED21 MED9 USP47
Entrez ID		9968	55588
HPRD ID		02176	13748
Ensembl ID		ENSG00000184634	ENSG00000063322
Uniprot IDs		Q93074	B4DUA7 Q9NX70
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gland Morphogenesis Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Lipid Mammary Gland Branching Involved In Pregnancy Intracellular Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Tissue Morphogenesis Cellular Response To Lipid Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Morphogenesis Of An Epithelium Negative Regulation Of Gene Expression Mammary Gland Development Regulation Of Metabolic Process Response To Organic Substance Regulation Of Organ Morphogenesis Positive Regulation Of Cellular Metabolic Process Epithelial Tube Morphogenesis Regulation Of Cell Proliferation Mammary Gland Morphogenesis Tube Development Negative Regulation Of Transcription, DNA-templated Tube Morphogenesis	Androgen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Maintenance Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Stem Cell Development Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cell Differentiation Stem Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Axis Elongation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Cell Development Base-excision Repair Thyroid Hormone Mediated Signaling Pathway Positive Regulation Of Metabolic Process Cellular Metabolic Process Developmental Growth Involved In Morphogenesis Enucleate Erythrocyte Development Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of G0 To G1 Transition Axis Elongation Involved In Somitogenesis Depyrimidination Regulation Of Organ Morphogenesis
Tagcloud ?		accounting actionable amplifications borderline cnas confined defines deleterious drive druggable exclusively expands ffpe fibroepithelial formalin g44 grades hotspot identifies landscape mutational neurofibromin nf1 ngs phyllodes rb1 retinoblastoma spanning suppressors
Tagcloud (Difference) ?		accounting actionable amplifications borderline cnas confined defines deleterious drive druggable exclusively expands ffpe fibroepithelial formalin g44 grades hotspot identifies landscape mutational neurofibromin nf1 ngs phyllodes rb1 retinoblastoma spanning suppressors
Tagcloud (Intersection) ?