MED12 and SOX9

Number of citations of the paper that reports this interaction (PMID 12136106)
22

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)
HPRD (in vivo, in vitro)

		MED12	SOX9
Gene Name		mediator complex subunit 12	SRY (sex determining region Y)-box 9
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Centrosome Membrane Mediator Complex	Nucleus Nucleoplasm Protein Complex Nuclear Transcription Factor Complex
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Enhancer Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Kinase Activity Protein Binding Beta-catenin Binding Protein Kinase A Catalytic Subunit Binding Enhancer Binding BHLH Transcription Factor Binding Protein Heterodimerization Activity Pre-mRNA Intronic Binding
	Biological Process	Neural Tube Closure Transcription Initiation From RNA Polymerase II Promoter Heart Development Gene Expression Oligodendrocyte Development Schwann Cell Development Stem Cell Maintenance Negative Regulation Of Wnt Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Axis Elongation Involved In Somitogenesis	Skeletal System Development Cartilage Condensation Ossification Branching Involved In Ureteric Bud Morphogenesis Cell Fate Specification Epithelial To Mesenchymal Transition Tissue Homeostasis Positive Regulation Of Protein Phosphorylation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Immune System Process Heart Valve Development Heart Valve Morphogenesis Heart Valve Formation Endocardial Cushion Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Chondrocyte Hypertrophy Nucleosome Assembly Chromatin Remodeling Transcription From RNA Polymerase II Promoter Protein Complex Assembly Protein Phosphorylation Cytoskeleton Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Spermatogenesis Positive Regulation Of Cell Proliferation Male Gonad Development Regulation Of Cell Cycle Process Positive Regulation Of Epithelial Cell Migration Neural Crest Cell Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Single Organismal Cell-cell Adhesion Male Germ-line Sex Determination CAMP-mediated Signaling Regulation Of Cell Adhesion Extracellular Matrix Organization Negative Regulation Of Ossification Negative Regulation Of Bone Mineralization Prostate Gland Development Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Mammary Gland Development Notochord Development Otic Vesicle Formation Endocrine Pancreas Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Somatic Stem Cell Maintenance Intrahepatic Bile Duct Development Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Myoblast Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Photoreceptor Cell Differentiation Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Cartilage Development Sertoli Cell Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Limb Bud Formation Retinal Rod Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Intestinal Epithelial Structure Maintenance Regulation Of Cell Proliferation Involved In Tissue Homeostasis Positive Regulation Of Cartilage Development Regulation Of Branching Involved In Lung Morphogenesis Morphogenesis Of A Branching Epithelium Negative Regulation Of Biomineral Tissue Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Interleukin-1 Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Heparin Cellular Response To Transforming Growth Factor Beta Stimulus Renal Vesicle Induction Ureter Urothelium Development Ureter Smooth Muscle Cell Differentiation Ureter Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Male Gonad Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Pulmonary function (interaction) ( 23284291) Pulmonary function decline ( 22424883) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		17 interactors: CDK8 ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED29 MED8 MED9 MYC NANOG PPARGC1A SOX9 SREBF1 VDR	14 interactors: ATP6V1H CREB1 CREB3L4 CREBBP EP300 HERC1 HSPA1A KPNB1 MAF MED12 NR5A1 RUNX2 SPEN TRAF2
Entrez ID		9968	6662
HPRD ID		02176	06427
Ensembl ID		ENSG00000184634	ENSG00000125398
Uniprot IDs		Q93074	P48436
PDB IDs			1S9M 1SX9 4EUW
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gland Morphogenesis Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Lipid Mammary Gland Branching Involved In Pregnancy Intracellular Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Tissue Morphogenesis Cellular Response To Lipid Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Morphogenesis Of An Epithelium Negative Regulation Of Gene Expression Mammary Gland Development Regulation Of Metabolic Process Response To Organic Substance Regulation Of Organ Morphogenesis Positive Regulation Of Cellular Metabolic Process Epithelial Tube Morphogenesis Regulation Of Cell Proliferation Mammary Gland Morphogenesis Tube Development Negative Regulation Of Transcription, DNA-templated Tube Morphogenesis	Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Viral Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Transcription, DNA-templated Notch Signaling Pathway RNA Metabolic Process RNA Biosynthetic Process Response To Organic Substance Transcription Initiation From RNA Polymerase II Promoter Gene Expression Cellular Response To Organic Substance Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Heat DNA-templated Transcription, Initiation Cellular Response To Stimulus Signal Transduction Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Stabilization Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Acetylation Signaling Rhythmic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cell Communication Response To Heat Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Unfolded Protein
Tagcloud ?		accounting actionable amplifications borderline cnas confined defines deleterious drive druggable exclusively expands ffpe fibroepithelial formalin g44 grades hotspot identifies landscape mutational neurofibromin nf1 ngs phyllodes rb1 retinoblastoma spanning suppressors	atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish
Tagcloud (Difference) ?		accounting actionable amplifications borderline cnas confined defines deleterious drive druggable exclusively expands ffpe fibroepithelial formalin g44 grades hotspot identifies landscape mutational neurofibromin nf1 ngs phyllodes rb1 retinoblastoma spanning suppressors	atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish
Tagcloud (Intersection) ?