MED12 and MED1

Number of citations of the paper that reports this interaction (PMID 15175163)
80

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MED12	MED1
Gene Name		mediator complex subunit 12	mediator complex subunit 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Centrosome Membrane Mediator Complex	Chromatin Nucleus Nucleoplasm Nucleolus Membrane Mediator Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Transcription Cofactor Activity Chromatin Binding Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Thyroid Hormone Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Mediator Complex Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Thyroid Hormone Receptor Binding LBD Domain Binding
	Biological Process	Neural Tube Closure Transcription Initiation From RNA Polymerase II Promoter Heart Development Gene Expression Oligodendrocyte Development Schwann Cell Development Stem Cell Maintenance Negative Regulation Of Wnt Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Axis Elongation Involved In Somitogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Angiogenesis Liver Development Embryonic Placenta Development Lens Development In Camera-type Eye Thyroid Hormone Mediated Signaling Pathway Ventricular Trabecula Myocardium Morphogenesis Retinal Pigment Epithelium Development Regulation Of Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase II Promoter Thyroid Hormone Generation Androgen Biosynthetic Process Brain Development Lactation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Monocyte Differentiation Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Organ Regeneration Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Heart Tube Development Embryonic Hindlimb Morphogenesis Embryonic Hemopoiesis Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Megakaryocyte Development MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Fat Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Erythrocyte Development Enucleate Erythrocyte Development Regulation Of Cell Cycle Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Mammary Gland Branching Involved In Thelarche Mammary Gland Branching Involved In Pregnancy Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of G0 To G1 Transition ERK1 And ERK2 Cascade Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Receptor Activity Positive Regulation Of Hepatocyte Proliferation Regulation Of RNA Biosynthetic Process
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CDK8 ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED29 MED8 MED9 MYC NANOG PPARGC1A SOX9 SREBF1 VDR	42 interactors: AR BRCA1 CTDP1 ESR1 ESR2 EZH2 GABPA GATA1 GATA3 GATA4 GATA6 GJB5 HNF4A KIF1A MDM2 MED12 MED14 MED25 MED29 MED8 MED9 MYC NCOA6 NR1H2 NR1I3 NR3C1 NR4A1 PIN1 PPARA PPARG PPARGC1A RARA RORA RXRA RXRB SREBF1 THRA THRB TP53 VDR YWHAH YWHAQ
Entrez ID		9968	5469
HPRD ID		02176	05055
Ensembl ID		ENSG00000184634	ENSG00000125686
Uniprot IDs		Q93074	Q15648
PDB IDs			1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 3A2H 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW 3W5P 3W5Q 3W5R 3W5T
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gland Morphogenesis Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Lipid Mammary Gland Branching Involved In Pregnancy Intracellular Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Tissue Morphogenesis Cellular Response To Lipid Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Morphogenesis Of An Epithelium Negative Regulation Of Gene Expression Mammary Gland Development Regulation Of Metabolic Process Response To Organic Substance Regulation Of Organ Morphogenesis Positive Regulation Of Cellular Metabolic Process Epithelial Tube Morphogenesis Regulation Of Cell Proliferation Mammary Gland Morphogenesis Tube Development Negative Regulation Of Transcription, DNA-templated Tube Morphogenesis	Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Hormone-mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Steroid Hormone Stimulus RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Hormone Stimulus Response To Hormone Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Lipid Response To Lipid Regulation Of Transcription, DNA-templated RNA Metabolic Process Response To Organic Cyclic Compound Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Substance Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		accounting actionable amplifications borderline cnas confined defines deleterious drive druggable exclusively expands ffpe fibroepithelial formalin g44 grades hotspot identifies landscape mutational neurofibromin nf1 ngs phyllodes rb1 retinoblastoma spanning suppressors	adam9 aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4
Tagcloud (Difference) ?		accounting actionable amplifications borderline cnas confined defines deleterious drive druggable exclusively expands ffpe fibroepithelial formalin g44 grades hotspot identifies landscape mutational neurofibromin nf1 ngs phyllodes rb1 retinoblastoma spanning suppressors	adam9 aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4
Tagcloud (Intersection) ?