MED12 and GLI3

Number of citations of the paper that reports this interaction (PMID 17000779)
28

Data Source:
BioGRID (two hybrid, pull down)

		MED12	GLI3
Gene Name		mediator complex subunit 12	GLI family zinc finger 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Centrosome Membrane Mediator Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Mediator Complex Nuclear Speck Transcriptional Repressor Complex Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Transcription Initiation From RNA Polymerase II Promoter Heart Development Gene Expression Oligodendrocyte Development Schwann Cell Development Stem Cell Maintenance Negative Regulation Of Wnt Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Axis Elongation Involved In Somitogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Metanephros Development Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Transcription, DNA-templated Smoothened Signaling Pathway Axon Guidance Hindgut Morphogenesis Heart Development Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Protein Processing Optic Nerve Morphogenesis Hippocampus Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Forebrain Dorsal/ventral Pattern Formation Cerebral Cortex Radial Glia Guided Migration Forebrain Radial Glial Cell Differentiation Lateral Ganglionic Eminence Cell Proliferation Melanocyte Differentiation Lung Development Positive Regulation Of Chondrocyte Differentiation T Cell Differentiation In Thymus Limb Morphogenesis Wound Healing Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Nose Morphogenesis Tongue Development Response To Estrogen Negative Thymic T Cell Selection Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Camera-type Eye Morphogenesis Embryonic Skeletal System Morphogenesis Oligodendrocyte Differentiation Palate Development Frontal Suture Morphogenesis Lambdoid Suture Morphogenesis Sagittal Suture Morphogenesis Mammary Gland Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Artery Development Anterior Semicircular Canal Development Lateral Semicircular Canal Development Cell Differentiation Involved In Kidney Development Thymocyte Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 is processed to GLI3R by the proteasome
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Allergic rhinitis ( 22036096)
Protein-Protein Interactions		17 interactors: CDK8 ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED29 MED8 MED9 MYC NANOG PPARGC1A SOX9 SREBF1 VDR	17 interactors: BTRC CREBBP CSNK1A1 GSK3A MED12 PRKCA SKI SMAD1 SMAD2 SMAD3 SMAD4 STK36 SUFU TWIST1 ZIC1 ZIC2 ZIC3
Entrez ID		9968	2737
HPRD ID		02176	01313
Ensembl ID		ENSG00000184634	ENSG00000106571
Uniprot IDs		Q93074	P10071
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gland Morphogenesis Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Lipid Mammary Gland Branching Involved In Pregnancy Intracellular Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Tissue Morphogenesis Cellular Response To Lipid Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Morphogenesis Of An Epithelium Negative Regulation Of Gene Expression Mammary Gland Development Regulation Of Metabolic Process Response To Organic Substance Regulation Of Organ Morphogenesis Positive Regulation Of Cellular Metabolic Process Epithelial Tube Morphogenesis Regulation Of Cell Proliferation Mammary Gland Morphogenesis Tube Development Negative Regulation Of Transcription, DNA-templated Tube Morphogenesis	Embryonic Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Tube Morphogenesis Tissue Morphogenesis Positive Regulation Of Transcription, DNA-templated Tube Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Embryo Development Epithelial Tube Morphogenesis Organ Development SMAD Protein Complex Assembly Pattern Specification Process Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Cell Differentiation Epithelium Development Positive Regulation Of Cellular Metabolic Process Heart Development Morphogenesis Of An Epithelium Regulation Of Cell Differentiation Regulation Of Signal Transduction Cardiovascular System Development Tissue Development Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Stem Cell Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter System Development Regulation Of Transcription, DNA-templated Stem Cell Maintenance Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Developmental Process Stem Cell Differentiation Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Transcription From RNA Polymerase II Promoter Response To Growth Factor Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Primary MiRNA Processing
Tagcloud ?		accounting actionable amplifications borderline cnas confined defines deleterious drive druggable exclusively expands ffpe fibroepithelial formalin g44 grades hotspot identifies landscape mutational neurofibromin nf1 ngs phyllodes rb1 retinoblastoma spanning suppressors	act antitumor application blocks cancers combined component could cyclopamine directions downstream enhance glioma gynecological hedgehog induce leading malignancy management mortality oncogene ovarian pathway proliferation reduce signaling silencing therefore
Tagcloud (Difference) ?		accounting actionable amplifications borderline cnas confined defines deleterious drive druggable exclusively expands ffpe fibroepithelial formalin g44 grades hotspot identifies landscape mutational neurofibromin nf1 ngs phyllodes rb1 retinoblastoma spanning suppressors	act antitumor application blocks cancers combined component could cyclopamine directions downstream enhance glioma gynecological hedgehog induce leading malignancy management mortality oncogene ovarian pathway proliferation reduce signaling silencing therefore
Tagcloud (Intersection) ?