HOXC10 and CDC27

Number of citations of the paper that reports this interaction (PMID 12853486)
21

Data Source:
HPRD (in vitro, in vivo)

		HOXC10	CDC27
Gene Name		homeobox C10	cell division cycle 27
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Spindle Microtubule
	Molecular Function	Sequence-specific DNA Binding	Protein Binding Protein Phosphatase Binding
	Biological Process	Skeletal System Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Spinal Cord Motor Neuron Cell Fate Specification Embryonic Limb Morphogenesis Neuromuscular Process	Mitotic Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination
Pathways			Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CDC27 EGFR NUP205 YWHAG	30 interactors: ADNP ANAPC10 ANAPC2 ANAPC7 BUB1B CASP3 CCNA2 CCNB1 CDC16 CDC20 CDC26 CKS1B COMT CTNNB1 DCPS FBXO5 FZR1 GKN1 HOXC10 HSF2 MAD2L1 PIN1 PPP5C PTEN PTTG1 RB1 SKIL SMAD2 SMAD3 UBE2S
Entrez ID		3226	996
HPRD ID		05710	00304
Ensembl ID		ENSG00000180818	ENSG00000004897
Uniprot IDs		Q53XI4 Q9NYD6	B4DL80 G5EA36 P30260
PDB IDs			3T1N
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Negative Regulation Of Protein Catabolic Process Alkanesulfonate Metabolic Process Membrane Organization Negative Regulation Of Protein Metabolic Process Protein Import Into Nucleus, Docking Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Intracellular Transport Activation Of Phospholipase A2 Activity Cellular Protein Localization Positive Regulation Of Phospholipase A2 Activity Establishment Of Protein Localization Response To Cobalamin Response To UV-A Negative Regulation Of Transferase Activity Regulation Of Synaptic Transmission Nuclear Pore Complex Assembly Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Metaphase/anaphase Transition Of Mitotic Cell Cycle Nuclear Pore Organization Regulation Of Protein Catabolic Process Positive Regulation Of Catenin Import Into Nucleus Regulation Of Mitotic Cell Cycle Protein Targeting Cellular Response To Organic Substance Pore Complex Assembly Regulation Of Phospholipase A2 Activity Regulation Of Intracellular Transport Protein Localization Regulation Of Superoxide Anion Generation Negative Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cellular Response To Organonitrogen Compound Magnesium Ion Homeostasis Regulation Of Protein Metabolic Process Cellular Response To Estradiol Stimulus Positive Regulation Of Transferase Activity Cellular Response To Hormone Stimulus Protein Insertion Into Membrane Astrocyte Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity	Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Ligase Activity Mitotic Nuclear Division Cell Cycle Process Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Cell Cycle Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Cycle Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Mitotic Spindle Checkpoint Negative Regulation Of Protein Catabolic Process
Tagcloud ?		ai ais antiestrogen aromatase blockade concurrent confers contributing cpg delaying enrichment h3k27me3 homeobox hyper hypermethylation hypomethylation overlapped paired permanent recurred relief represses repression shore supporting transitioning ultimately widespread xenografts	aiming applying backgroundosteosarcoma chromotripsis cnvs conclusionsthe confirmative ei24 exome germline homodimer igf1 igf2 indels markwe metastasizing methodsfor muc4 mucin os qualify rearrangements resultsin seq snvs softwares somatic tumorous urgent
Tagcloud (Difference) ?		ai ais antiestrogen aromatase blockade concurrent confers contributing cpg delaying enrichment h3k27me3 homeobox hyper hypermethylation hypomethylation overlapped paired permanent recurred relief represses repression shore supporting transitioning ultimately widespread xenografts	aiming applying backgroundosteosarcoma chromotripsis cnvs conclusionsthe confirmative ei24 exome germline homodimer igf1 igf2 indels markwe metastasizing methodsfor muc4 mucin os qualify rearrangements resultsin seq snvs softwares somatic tumorous urgent
Tagcloud (Intersection) ?