KIAA0020 and HPS6

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		KIAA0020	HPS6
Gene Name		KIAA0020	Hermansky-Pudlak syndrome 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum	Endoplasmic Reticulum Membrane BLOC-2 Complex Early Endosome Membrane
	Molecular Function	MRNA Binding Poly(A) RNA Binding	Rab GTPase Binding GTP-dependent Protein Binding
	Biological Process	Regulation Of Translation	Organelle Organization Blood Coagulation Melanocyte Differentiation Protein Localization To Membrane
Pathways
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: CALM1 HPS6	9 interactors: CREB1 EP300 HPS5 KIAA0020 MARK4 MNAT1 OSGEP PIK3CB TTC19
Entrez ID		9933	79803
HPRD ID		08822	08471
Ensembl ID		ENSG00000080608	ENSG00000166189
Uniprot IDs		Q15397	Q86YV9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Blood Coagulation Hemostasis Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Wounding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Membrane Organization Positive Regulation Of Nitric-oxide Synthase Activity Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Positive Regulation Of Phosphatase Activity Response To Corticosterone Positive Regulation Of Cation Channel Activity Response To Amphetamine Positive Regulation Of Adenylate Cyclase Activity Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Nitric-oxide Synthase Activity Response To Mineralocorticoid Substantia Nigra Development Positive Regulation Of Oxidoreductase Activity Melanocyte Differentiation Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Viral Process Cell Cycle Process Histone H2B Acetylation Protein Stabilization Posttranscriptional Regulation Of Gene Expression Threonylcarbamoyladenosine Biosynthetic Process Viral Process Cell Cycle Regulation Of Body Fluid Levels Phosphatidylinositol-mediated Signaling N-terminal Peptidyl-lysine Acetylation Regulation Of Protein Stability Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Viral Process G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Mitotic Cell Cycle Process Circadian Rhythm Threonylcarbamoyladenosine Metabolic Process Regulation Of Tubulin Deacetylation Cellular Response To Fibroblast Growth Factor Stimulus Mitotic Cell Cycle Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Organelle Organization Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Lung Development Positive Regulation By Host Of Viral Transcription Embryonic Cleavage Mitochondrial Respiratory Chain Complex III Assembly Respiratory Tube Development Regulation Of Cellular Protein Metabolic Process Response To Hormone Fc Receptor Signaling Pathway N-terminal Protein Amino Acid Acetylation Response To Stress Regulation Of Clathrin-mediated Endocytosis Lung Saccule Development
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