HELZ and SMYD3

Number of citations of the paper that reports this interaction (PMID 15235609)
97

Data Source:
HPRD (in vitro, in vivo)

		HELZ	SMYD3
Gene Name		helicase with zinc finger	SET and MYND domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Membrane	Nucleoplasm Cytoplasm
	Molecular Function	Helicase Activity ATP Binding Poly(A) RNA Binding Metal Ion Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding
	Biological Process	Metabolic Process	Chromatin Organization Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Dexamethasone Stimulus
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: GRB2 SH3YL1 SMYD3 STAT5A	16 interactors: APP CAMK2B CYP39A1 EED EZH2 H3F3C HELZ HIST3H3 HSP90AA1 NDUFAB1 NFYB PBX2 POLR2K TRIT1 VANGL1 ZNF557
Entrez ID		9931	64754
HPRD ID		10452	12297
Ensembl ID		ENSG00000198265	ENSG00000185420
Uniprot IDs		J3QS41	B3KN46 Q9H7B4
PDB IDs			3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0
Enriched GO Terms of Interacting Partners?		Cellular Response To Hormone Stimulus Positive Regulation Of Mast Cell Differentiation Response To Hormone Positive Regulation Of T Cell Activation Regulation Of Mast Cell Differentiation Development Of Secondary Male Sexual Characteristics Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Mast Cell Apoptotic Process Creatinine Metabolic Process Regulation Of T Cell Activation Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Mast Cell Proliferation Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Isoleucine Metabolic Process Allantoin Metabolic Process Cellular Response To Peptide Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Regulation Of Lymphocyte Activation Valine Metabolic Process Creatine Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Natural Killer Cell Differentiation Succinate Metabolic Process Cellular Response To Organic Substance Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics Luteinization Response To Peptide Hormone Positive Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Cell Activation Cellular Response To Organonitrogen Compound Response To Peptide Positive Regulation Of B Cell Differentiation Reproductive Structure Development Reproductive System Development 2-oxoglutarate Metabolic Process Peyer's Patch Development Morphogenesis Of An Epithelium Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Epithelial Cell Differentiation Involved In Prostate Gland Development	Negative Regulation Of Gene Expression, Epigenetic Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Inhibitory G-protein Coupled Receptor Phosphorylation Positive Regulation Of Cellular Metabolic Process Cellular Response To Heat Neuromuscular Process Controlling Balance Synaptic Growth At Neuromuscular Junction Activation Of Meiosis Involved In Egg Activation Innate Immune Response Regulation Of Synapse Structure Or Activity Cellular Metabolic Process Bile Acid Catabolic Process Collateral Sprouting In Absence Of Injury Response To Heat Transcription, DNA-templated Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Protein Import Into Mitochondrial Outer Membrane Activation Of Meiosis Cholesterol Metabolic Process Histone Methylation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Protein Lipoylation Sterol Metabolic Process Neuromuscular Process Regulation Of Cell Cycle Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Metabolic Process Gene Expression Regulation Of Synaptic Transmission, Cholinergic Axon Choice Point Recognition
Tagcloud ?			blocked bovine conversely early embryonic embryos epigenetic fertilization germinal involves lysine mammalian maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle
Tagcloud (Difference) ?			blocked bovine conversely early embryonic embryos epigenetic fertilization germinal involves lysine mammalian maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle
Tagcloud (Intersection) ?