HELZ and SMYD3

Number of citations of the paper that reports this interaction (PubMedID 15235609)
0

Data Source:
HPRD (in vitro, in vivo)

		HELZ	SMYD3
Description		helicase with zinc finger	SET and MYND domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Membrane P Granule	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Regulatory NcRNA-mediated Post-transcriptional Gene Silencing	Chromatin Organization Nucleosome Assembly Myotube Cell Development Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Putamen volume ( 29147026) Visceral fat ( 30942860)	Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) DHEAS levels ( 34748635) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Malaria ( 31844061) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Renal underexcretion gout ( 32238385) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)
Interacting Genes		4 interacting genes: GRB2 SH3YL1 SMYD3 STAT5A	25 interacting genes: APP CAMK2B CFTR CSTF2T CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 LCOR MAP3K2 MKRN3 NDUFAB1 NFYB NUP54 PBX2 PKN1 POLR2K RNF113A SHC3 TRIT1 VANGL1 ZNF557
Entrez ID		9931	64754
HPRD ID		10452	12297
Ensembl ID		ENSG00000198265	ENSG00000185420
Uniprot IDs		A0A2P0H7U5 B7ZLW2 J3QS41 P42694	B3KN46 Q9H7B4
PDB IDs			3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL 6O9O 6P6G 6P6K 6P7Z 6PAF 6YUH 6ZRB 7BJ1 7O2A 7O2B 7O2C 7QLB 7QNR 7QNU 8OWO
Enriched GO Terms of Interacting Partners?		Regulation Of Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Mediated Cytotoxicity Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Grb2-EGFR Complex Positive Regulation Of Mast Cell Differentiation Cell Development Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Killing Morphogenesis Of An Epithelium Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Lymphocyte Mediated Immunity T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Mast Cell Differentiation Interleukin-4-mediated Signaling Pathway Taurine Metabolic Process Epithelial Cell Differentiation Involved In Prostate Gland Development Development Of Secondary Female Sexual Characteristics Thrombopoietin-mediated Signaling Pathway Negative Regulation Of T-helper 17 Cell Lineage Commitment Negative Regulation Of Mast Cell Apoptotic Process Eosinophil Differentiation Mucosa-associated Lymphoid Tissue Development Interleukin-9-mediated Signaling Pathway Peyer's Patch Development Luteinization Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Erythrocyte Differentiation Interleukin-3-mediated Signaling Pathway Regulation Of Mast Cell Apoptotic Process Interleukin-7-mediated Signaling Pathway Activated T Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Interleukin-5-mediated Signaling Pathway Mast Cell Apoptotic Process Regulation Of Mast Cell Proliferation Interleukin-15-mediated Signaling Pathway Mast Cell Differentiation Development Of Secondary Sexual Characteristics	Nucleus Pronucleus Transcription Corepressor Binding Chromatin Silencing Complex
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