HELZ and SH3YL1

Number of citations of the paper that reports this interaction (PubMedID 12615363)
0

Data Source:
BioGRID (two hybrid)

		HELZ	SH3YL1
Description		helicase with zinc finger	SH3 and SYLF domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Membrane P Granule	Ruffle Membrane
	Molecular Function	Nucleotide Binding RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protein Binding Phosphatase Binding Phosphatidylinositol Binding
	Biological Process	Regulatory NcRNA-mediated Post-transcriptional Gene Silencing	Phosphatidylinositol Biosynthetic Process Regulation Of Ruffle Assembly
Pathways
Drugs
Diseases
GWAS		Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Putamen volume ( 29147026) Visceral fat ( 30942860)	A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Blood urea nitrogen levels ( 31152163) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Large artery stroke ( 28265093) Mitochondrial DNA levels ( 25240745) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: GRB2 SH3YL1 SMYD3 STAT5A	11 interacting genes: AR ERRFI1 GFAP HELZ KHDRBS1 PRB3 SH3D19 SYNJ1 VIM VPS37B ZBTB7B
Entrez ID		9931	26751
HPRD ID		10452	15336
Ensembl ID		ENSG00000198265	ENSG00000035115
Uniprot IDs		A0A2P0H7U5 B7ZLW2 J3QS41 P42694	Q96HL8
PDB IDs			2D8H
Enriched GO Terms of Interacting Partners?		Regulation Of Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Mediated Cytotoxicity Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Grb2-EGFR Complex Positive Regulation Of Mast Cell Differentiation Cell Development Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Killing Morphogenesis Of An Epithelium Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Lymphocyte Mediated Immunity T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Mast Cell Differentiation Interleukin-4-mediated Signaling Pathway Taurine Metabolic Process Epithelial Cell Differentiation Involved In Prostate Gland Development Development Of Secondary Female Sexual Characteristics Thrombopoietin-mediated Signaling Pathway Negative Regulation Of T-helper 17 Cell Lineage Commitment Negative Regulation Of Mast Cell Apoptotic Process Eosinophil Differentiation Mucosa-associated Lymphoid Tissue Development Interleukin-9-mediated Signaling Pathway Peyer's Patch Development Luteinization Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Erythrocyte Differentiation Interleukin-3-mediated Signaling Pathway Regulation Of Mast Cell Apoptotic Process Interleukin-7-mediated Signaling Pathway Activated T Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Interleukin-5-mediated Signaling Pathway Mast Cell Apoptotic Process Regulation Of Mast Cell Proliferation Interleukin-15-mediated Signaling Pathway Mast Cell Differentiation Development Of Secondary Sexual Characteristics	Bergmann Glial Cell Differentiation Astrocyte Development Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Induction Gene Expression Cellular Response To Steroid Hormone Stimulus Nuclear Receptor-mediated Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Schwann Cell Proliferation Astrocyte Differentiation Kinase Binding Intermediate Filament Organization Schwann Cell Proliferation Glial Cell Development Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Synaptic Vesicle Uncoating Positive Regulation Of Endosome Organization Grb2-Sos Complex Negative Regulation Of NK T Cell Activation Negative Regulation Of NK T Cell Proliferation Positive Regulation Of SREBP Signaling Pathway Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Positive Regulation Of Viral Budding Via Host ESCRT Complex Male Genitalia Morphogenesis POU Domain Binding Glial Cell Differentiation Phosphatidylinositol Phosphate 4-phosphatase Activity SH3 Domain Binding NK T Cell Differentiation Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Cellular Response To Lipid Negative Regulation Of Neuron Projection Development
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