TMCC2 and PTOV1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		TMCC2	PTOV1
Description		transmembrane and coiled-coil domain family 2	PTOV1 extended AT-hook containing adaptor protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding
	Biological Process	Amyloid Precursor Protein Metabolic Process	Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494 29403010 27863252) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 22139419 32888494 27863252 24026423 19820697) Meat-related diet ( 32066663) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 22139419 32888494) Platelet distribution width ( 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: ADRB2 AKT1 AMOTL2 APP CCDC33 CDR2 CFAP206 DIP2A DPY30 EIF4E2 FAM161A FAM74A4 FAM90A1 FBF1 HGS HNRNPLL HSPD1 IQUB KAT5 PRPF31 PTOV1 RHOXF2 SMO TLE5 UBA1 WT1-AS ZNF250 ZNF417 ZNF581 ZNF587 ZNF688	18 interacting genes: CCR4 DMTN DYRK1A HDAC1 HDAC4 HDAC6 HUWE1 NCOR1 PBK PIN1 PRKCD RACK1 RBPJ SGK2 SPTAN1 TMCC2 UBC USP16
Entrez ID		9911	53635
HPRD ID		11040	17929
Ensembl ID		ENSG00000133069	ENSG00000104960
Uniprot IDs		A0A0C4DFR1 O75069 Q8IW47	A0A0C4DGR2 M0QY25 Q86YD1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cilium Positive Regulation Of Protein Acetylation Ciliary Basal Body Regulation Of Multicellular Organism Growth Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Radial Spoke	Protein Modification Process Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Protein-containing Complex Assembly Protein Deacetylation Protein Lysine Deacetylase Activity Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Intracellular Signal Transduction Protein Metabolic Process Transcription Repressor Complex Histone Deacetylase Activity Macromolecule Deacylation Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of Protein Metabolic Process Histone Deacetylase Binding Circadian Rhythm Nucleoplasm Tau Protein Binding Chromatin Organization Post-translational Protein Modification Regulation Of Phosphorus Metabolic Process Negative Regulation Of Actin Filament Polymerization Negative Regulation Of MAPK Cascade Negative Regulation Of Catabolic Process Regulation Of Supramolecular Fiber Organization Chromatin Remodeling Negative Regulation Of Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Type 2 Mitophagy Regulation Of Translational Elongation Response To Stress Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Protein Depolymerization Regulation Of Organelle Organization Macromolecule Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myotube Differentiation
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