KIAA0196 and WASH1

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (affinity chromatography technology, two hybrid, biochemical)

		KIAA0196	WASH1
Gene Name		KIAA0196	WAS protein family homolog 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Endoplasmic Reticulum Cytosol WASH Complex	Exocyst Early Endosome Early Endosome Membrane Recycling Endosome Recycling Endosome Membrane WASH Complex Invadopodium
	Molecular Function	Protein Binding	Actin Binding Protein Binding Ubiquitin Protein Ligase Binding Alpha-tubulin Binding
	Biological Process	Endosomal Transport	Exocytosis Endosomal Transport Extracellular Matrix Disassembly Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Retrograde Transport, Endosome To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536)
Protein-Protein Interactions		2 interactors: FAM21C WASH1	5 interactors: BECN1 BLOC1S2 KIAA0196 KIAA1033 RNF2
Entrez ID		9897	100287171
HPRD ID		13786
Ensembl ID		ENSG00000164961
Uniprot IDs		E7EQI7 Q12768	A8K0Z3
PDB IDs
Enriched GO Terms of Interacting Partners?		Retrograde Transport, Endosome To Plasma Membrane Retrograde Transport, Endosome To Golgi Endosomal Transport Negative Regulation Of Barbed-end Actin Filament Capping Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Pseudopodium Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Arp2/3 Complex-mediated Actin Nucleation Vesicle-mediated Transport Intracellular Transport Actin Nucleation Regulation Of Cellular Component Organization Establishment Of Localization In Cell Extracellular Matrix Disassembly Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Assembly Positive Regulation Of Protein Polymerization Cellular Localization Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Regulation Of Cell-substrate Adhesion Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length	Endosomal Transport Intracellular Transport Cellular Response To Aluminum Ion Establishment Of Localization In Cell Positive Regulation Of Mitochondrion Degradation CVT Pathway Histone H2A-K119 Monoubiquitination Cellular Localization Response To Aluminum Ion Late Endosome To Vacuole Transport Organelle Organization Regulation Of Mitochondrion Degradation Mitochondrial Outer Membrane Permeabilization Platelet Dense Granule Organization Histone H2A Monoubiquitination Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Macroautophagy Histone H2A Ubiquitination Endomembrane System Organization Cellular Response To Nitrogen Starvation Positive Regulation Of Mitochondrial Membrane Permeability Response To Vitamin E Histone Monoubiquitination Anterograde Synaptic Vesicle Transport Nucleophagy Beta-amyloid Metabolic Process Microtubule Nucleation Melanosome Organization Protein Targeting To Vacuole Pigment Granule Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Epidermal Growth Factor Stimulus Establishment Of Protein Localization To Vacuole Microtubule Polymerization Anterograde Axon Cargo Transport Response To Epidermal Growth Factor Endosome Organization Histone Ubiquitination Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Autophagy Regulation Of Membrane Permeability Transport Secretory Granule Organization Protein Monoubiquitination Microtubule Polymerization Or Depolymerization Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Autophagic Vacuole Assembly Axon Cargo Transport Cellular Defense Response Lysosome Organization
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