KIAA0196 and FAM21C

Number of citations of the paper that reports this interaction (PMID 20923837)
36

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		KIAA0196	FAM21C
Gene Name		KIAA0196	family with sequence similarity 21, member C
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Endoplasmic Reticulum Cytosol WASH Complex	Endosome Early Endosome Plasma Membrane Early Endosome Membrane WASH Complex
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Endosomal Transport	Retrograde Transport, Endosome To Golgi Regulation Of Substrate Adhesion-dependent Cell Spreading Retrograde Transport, Endosome To Plasma Membrane Negative Regulation Of Barbed-end Actin Filament Capping
Pathways
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536)	Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978)
Protein-Protein Interactions		2 interactors: FAM21C WASH1	4 interactors: ATXN1 FKBP15 KIAA0196 VPS35
Entrez ID		9897	253725
HPRD ID		13786	11094
Ensembl ID		ENSG00000164961	ENSG00000172661
Uniprot IDs		E7EQI7 Q12768	A8K5W5 B3KMC4 Q9Y4E1
PDB IDs
Enriched GO Terms of Interacting Partners?		Retrograde Transport, Endosome To Plasma Membrane Retrograde Transport, Endosome To Golgi Endosomal Transport Negative Regulation Of Barbed-end Actin Filament Capping Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Pseudopodium Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Arp2/3 Complex-mediated Actin Nucleation Vesicle-mediated Transport Intracellular Transport Actin Nucleation Regulation Of Cellular Component Organization Establishment Of Localization In Cell Extracellular Matrix Disassembly Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Assembly Positive Regulation Of Protein Polymerization Cellular Localization Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Regulation Of Cell-substrate Adhesion Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length	Negative Regulation Of Late Endosome To Lysosome Transport Endosomal Transport Intracellular Transport Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Retrograde Transport, Endosome To Plasma Membrane Transport Transcytosis Establishment Of Localization In Cell Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Localization
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