RB1CC1 and SYN1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		RB1CC1	SYN1
Description		RB1 inducible coiled-coil 1	synapsin I
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Autophagosome Membrane Nucleus Cytoplasm Lysosome Vacuole Endoplasmic Reticulum Membrane Cytosol Organelle Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex	Synaptonemal Complex Golgi Apparatus Cytoskeleton Synaptic Vesicle Postsynaptic Density Axon Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Cell Body Synapse Presynaptic Active Zone Schaffer Collateral - CA1 Synapse Presynapse Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Protein-membrane Adaptor Activity Molecular Adaptor Activity	Actin Binding Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Calcium-dependent Protein Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Liver Development Autophagy Apoptotic Process Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Ribophagy Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Defense Response To Virus Reticulophagy Glycophagy Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Neurotransmitter Secretion Neuron Development Modulation Of Chemical Synaptic Transmission Synapse Organization Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Cycle Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways		Macroautophagy	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Sensory processing of sound by inner hair cells of the cochlea
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Body size at age 10 ( 32376654) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651) Mitochondrial DNA copy number (white blood cells) ( 30704525) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		35 interacting genes: ATG12 AZI2 BAP1 BLID CALCOCO2 COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MECOM MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 THRSP UBC UMPS VAPA VHL VPS45 WIF1	30 interacting genes: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 RB1CC1 S100A1 SNCA SPTAN1 SRC SYN2 SYN3 VIM
Entrez ID		9821	6853
HPRD ID		06019	02433
Ensembl ID		ENSG00000023287	ENSG00000008056
Uniprot IDs		Q8TDY2	P17600
PDB IDs		6DCE 6GMA 7CZG 7CZM 7D0E 7EA2 7EAA 8SOI 8SQZ 8SRM 8W6B 8YFK 8YFL 8YFM 8YFN 9C82 9D34
Enriched GO Terms of Interacting Partners?		Autophagosome Membrane Autophagosome Cellular Response To Nitrogen Starvation Autophagosome Maturation Phosphatidylethanolamine Binding GABA Receptor Binding Autophagy Of Mitochondrion Macroautophagy Autophagosome Assembly Autophagosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Signal Complex Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein-containing Complex Disassembly Mitophagy Glycophagy Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process Ubiquitin Protein Ligase Binding Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Vacuole Organization Regulation Of Autophagosome Maturation Programmed Cell Death Cell Death ERBB Signaling Pathway Protein Localization To Endoplasmic Reticulum Positive Regulation Of Proteolysis Glycogen Catabolic Process Regulation Of Proteolysis Histone H3 Methyltransferase Activity Catabolic Process Polysaccharide Catabolic Process Regulation Of Macrophage Chemotaxis Cellular Response To Fluid Shear Stress Neurotransmitter Receptor Regulator Activity Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Golgi Membrane Phospholipid Binding Heparosan-N-sulfate-glucuronate 5-epimerase Activity Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H3K4 Dimethyltransferase Activity	Cytosol Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Vesicle-mediated Transport In Synapse Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Biological Quality Regulation Of Organelle Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Postsynaptic Density Regulation Of Cellular Localization Presynaptic Endocytosis Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Cytoplasm Regulation Of Protein-containing Complex Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Actin Filament Polymerization Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Neurotrophin TRKA Receptor Binding Protein Serine Kinase Activity Protein Kinase Activity Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cellular Component Size Cellular Response To Nutrient Levels Protein Serine/threonine Kinase Activity Glutamatergic Synapse Actin Filament-based Process Cytoskeleton Organization Regulation Of Developmental Process Regulation Of Neuron Projection Development Kinase Activity Regulation Of Innate Immune Response Regulation Of Transport Cell Junction Organization Response To Growth Factor Regulation Of Heart Contraction Positive Regulation Of Protein-containing Complex Assembly
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