RB1CC1 and EPSTI1

Number of citations: 0 (PubMedID 25640309)
Data Source: BioGRID (two hybrid)

		RB1CC1	EPSTI1
Name		RB1 inducible coiled-coil 1	epithelial stromal interaction 1
Structure			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Autophagosome Membrane Nucleus Cytoplasm Lysosome Vacuole Endoplasmic Reticulum Membrane Cytosol Organelle Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex	None
	Molecular Function	Protein Binding Protein Kinase Binding Protein-membrane Adaptor Activity Molecular Adaptor Activity	Protein Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Liver Development Autophagy Apoptotic Process Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Ribophagy Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Defense Response To Virus Reticulophagy Glycophagy Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	None
Pathways		Macroautophagy	RND1 GTPase cycle
GWAS		Body size at age 10 ( 32376654 ) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651 ) Mitochondrial DNA copy number (white blood cells) ( 30704525 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 28552196 )	Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325 ) Dimensional psychopathology (Arousal) ( 29496196 ) Heel bone mineral density ( 30598549 ) Irritable bowel syndrome ( 29626450 ) Obesity-related traits ( 23251661 ) Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309 ) Severe aplastic anemia ( 32004448 )
Interacting Genes		35 interacting genes: ATG12 AZI2 BAP1 BLID CALCOCO2 COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MECOM MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 THRSP UBC UMPS VAPA VHL VPS45 WIF1	13 interacting genes: AKT1 AURKA BAG4 BCAR3 CASP8 ESR1 FGFR4 FZR1 NOTCH2 PPM1D PTPRJ RB1CC1 VCP
Entrez ID		9821	94240
HPRD ID		06019	06309
Ensembl ID		ENSG00000023287	ENSG00000133106
Uniprot IDs		Q8TDY2	Q96J88
PDB IDs		6DCE 6GMA 7CZG 7CZM 7D0E 7EA2 7EAA 8SOI 8SQZ 8SRM 8W6B 8YFK 8YFL 8YFM 8YFN 9C82 9D34	Not available
GO Terms Enriched among Interactors		Autophagosome Membrane Autophagosome Cellular Response To Nitrogen Starvation Autophagosome Maturation Phosphatidylethanolamine Binding GABA Receptor Binding Autophagy Of Mitochondrion Macroautophagy Autophagosome Assembly Autophagosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Signal Complex Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein-containing Complex Disassembly Mitophagy Glycophagy Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process Ubiquitin Protein Ligase Binding Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Vacuole Organization Regulation Of Autophagosome Maturation Programmed Cell Death Cell Death ERBB Signaling Pathway Protein Localization To Endoplasmic Reticulum Positive Regulation Of Proteolysis Glycogen Catabolic Process Regulation Of Proteolysis Histone H3 Methyltransferase Activity Catabolic Process Polysaccharide Catabolic Process Regulation Of Macrophage Chemotaxis Cellular Response To Fluid Shear Stress Neurotransmitter Receptor Regulator Activity Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Golgi Membrane Phospholipid Binding Heparosan-N-sulfate-glucuronate 5-epimerase Activity Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H3K4 Dimethyltransferase Activity	Regulation Of Intracellular Signal Transduction Positive Regulation Of Proteolysis Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Signal Transduction Nitric-oxide Synthase Regulator Activity Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Protein Kinase Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Animal Organ Development Positive Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Fibroblast Migration Liver Development Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Protein Autophosphorylation Response To Tumor Necrosis Factor Proteolysis Involved In Protein Catabolic Process Mitogen-activated Protein Kinase Binding