AARS1 and EEF1B2

Number of citations: 0 (PubMedID 11829477)
Data Source: HPRD (two hybrid)

		AARS1	EEF1B2
Name		alanyl-tRNA synthetase 1	eukaryotic translation elongation factor 1 beta 2
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Ser-tRNA(Ala) Deacylase Activity Nucleic Acid Binding RNA Binding Aminoacyl-tRNA Ligase Activity Alanine-tRNA Ligase Activity ATP Binding Zinc Ion Binding Amino Acid Binding Ligase Activity Metal Ion Binding Peptide Lactyltransferase (ATP-dependent) Activity	Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	TRNA Modification Translation TRNA Aminoacylation For Protein Translation Alanyl-tRNA Aminoacylation TRNA Processing Cerebellar Purkinje Cell Layer Development DNA Damage Response, Signal Transduction By P53 Class Mediator Hippo Signaling Positive Regulation Of Hippo Signaling TRNA Aminoacylation Negative Regulation Of Neuron Apoptotic Process Neuromuscular Process Controlling Balance Neuromuscular Process Neuron Apoptotic Process Aminoacyl-tRNA Metabolism Involved In Translational Fidelity Regulation Of Cytoplasmic Translational Fidelity Negative Regulation Of Signal Transduction By P53 Class Mediator	Translation Translational Elongation Response To Ethanol
Pathways		Cytosolic tRNA aminoacylation	Eukaryotic Translation Elongation
Drugs		Alanine	None
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	None
GWAS		No GWAS studies recorded	Body mass index ( 26426971 )
Interacting Genes		6 interacting genes: CDC42 CEBPA EEF1B2 HUNK LINC01554 SUMO2	15 interacting genes: AARS1 APP CEBPA CSNK2A1 CSNK2A2 DRD3 EEF1G HARS1 SPRYD4 TIMP1 TPT1 ULK2 USP7 VHL WBP2
Entrez ID		16	1933
HPRD ID		03042	02804
Ensembl ID		ENSG00000090861	ENSG00000114942
Uniprot IDs		A0A6Q8PH44 P49588	P24534
PDB IDs		4XEM 4XEO 5KNN 5T5S 5T76 5V59	1B64 5DQS
GO Terms Enriched among Interactors		None	Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Proteolysis Regulation Of Protein Catabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Signal Transduction Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Autophagy Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Collateral Sprouting Regulation Of Neurotransmitter Uptake Regulation Of Signal Transduction By P53 Class Mediator Protein Serine/threonine Kinase Binding Regulation Of Protein Metabolic Process Regeneration Regulation Of Membrane Protein Ectodomain Proteolysis Signal Transduction PcG Protein Complex Cellular Response To Stress Amyloid Fibril Formation Protein Metabolic Process Cytosol TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity DNA-binding Transcription Factor Binding TRNA Aminoacylation Response To Stress Macromolecule Metabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cytoplasmic Translational Fidelity