AARS1 and DHX38

		AARS1	DHX38
Description		alanyl-tRNA synthetase 1	DEAH-box helicase 38
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Ser-tRNA(Ala) Deacylase Activity Nucleic Acid Binding RNA Binding Aminoacyl-tRNA Ligase Activity Alanine-tRNA Ligase Activity ATP Binding Zinc Ion Binding Amino Acid Binding Ligase Activity Metal Ion Binding Peptide Lactyltransferase (ATP-dependent) Activity	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity
	Biological Process	TRNA Modification Translation TRNA Aminoacylation For Protein Translation Alanyl-tRNA Aminoacylation TRNA Processing Cerebellar Purkinje Cell Layer Development DNA Damage Response, Signal Transduction By P53 Class Mediator Hippo Signaling Positive Regulation Of Hippo Signaling TRNA Aminoacylation Negative Regulation Of Neuron Apoptotic Process Neuromuscular Process Controlling Balance Neuromuscular Process Neuron Apoptotic Process Aminoacyl-tRNA Metabolism Involved In Translational Fidelity Regulation Of Cytoplasmic Translational Fidelity Negative Regulation Of Signal Transduction By P53 Class Mediator	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		Cytosolic tRNA aminoacylation	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Alanine
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 23696881) Cholesterol, total ( 20686565 25961943) Coronary artery disease ( 29212778) Depression ( 29700475) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) LDL cholesterol ( 20686565 25961943) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 22916037) Red blood cell count ( 32888494) Serum metabolite levels (CMS) ( 31636271) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: CDC42 CEBPA EEF1B2 HUNK LINC01554 SUMO2	8 interacting genes: CDC40 CSNK2A1 MFAP1 PPP4C RNF10 SNRNP200 U2AF1 WBP4
Entrez ID		16	9785
HPRD ID		03042	05720
Ensembl ID		ENSG00000090861	ENSG00000140829
Uniprot IDs		A0A6Q8PH44 P49588	Q92620
PDB IDs		4XEM 4XEO 5KNN 5T5S 5T76 5V59	5YZG 6ZYM 7A5P 8I0W
Enriched GO Terms of Interacting Partners?			MRNA Metabolic Process MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Processing U2-type Precatalytic Spliceosome RNA Metabolic Process Nucleic Acid Metabolic Process Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Binding Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cytoplasmic Translational Fidelity Response To Injury Involved In Regulation Of Muscle Adaptation Negative Regulation Of Muscle Atrophy Chromatin Loop Anchoring Activity Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) Vitamin A Biosynthetic Process Beta-carotene Metabolic Process Nucleus Peptide Lactyltransferase (ATP-dependent) Activity Macromolecule Metabolic Process Ser-tRNA(Ala) Deacylase Activity Cis Assembly Of Pre-catalytic Spliceosome Carotene Metabolic Process Carotenoid Dioxygenase Activity Carotene Catabolic Process Nucleic Acid Binding
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