AARS1

Name	alanyl-tRNA synthetase 1
Structure
Novel Interactors	1 novel interactors: DHX38
Interactors	6 interactors: CDC42 CEBPA EEF1B2 HUNK LINC01554 SUMO2
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Ser-tRNA(Ala) Deacylase Activity Nucleic Acid Binding RNA Binding Aminoacyl-tRNA Ligase Activity Alanine-tRNA Ligase Activity ATP Binding Zinc Ion Binding Amino Acid Binding Ligase Activity Metal Ion Binding Peptide Lactyltransferase (ATP-dependent) Activity
	Biological Process	TRNA Modification Translation TRNA Aminoacylation For Protein Translation Alanyl-tRNA Aminoacylation TRNA Processing Cerebellar Purkinje Cell Layer Development DNA Damage Response, Signal Transduction By P53 Class Mediator Hippo Signaling Positive Regulation Of Hippo Signaling TRNA Aminoacylation Negative Regulation Of Neuron Apoptotic Process Neuromuscular Process Controlling Balance Neuromuscular Process Neuron Apoptotic Process Aminoacyl-tRNA Metabolism Involved In Translational Fidelity Regulation Of Cytoplasmic Translational Fidelity Negative Regulation Of Signal Transduction By P53 Class Mediator
Pathways	Cytosolic tRNA aminoacylation
Drugs	Alanine
Diseases	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS	No GWAS studies recorded
Entrez ID	16
HPRD ID	03042
Ensembl ID	ENSG00000090861
Uniprot IDs	A0A6Q8PH44 P49588
PDB IDs	4XEM 4XEO 5KNN 5T5S 5T76 5V59