SETD1A and BCKDK

Data Source: HiPPIP (Novel)

		SETD1A	BCKDK
Name		SET domain containing 1A, histone lysine methyltransferase	branched chain keto acid dehydrogenase kinase
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex	Mitochondrion Mitochondrial Matrix Oxoglutarate Dehydrogenase Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Beta-catenin Binding Methyltransferase Activity Transferase Activity Histone H3K4 Methyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3 Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Protein Serine Kinase Activity Catalytic Activity, Acting On A Protein
	Biological Process	Chromatin Organization Chromatin Remodeling DNA Damage Response Brain Development Methylation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Chromatin Organization	L-isoleucine Catabolic Process L-leucine Catabolic Process L-valine Catabolic Process Spermatogenesis Lipid Biosynthetic Process Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes	Branched-chain amino acid catabolism Branched-chain ketoacid dehydrogenase kinase deficiency
Drugs		None	Adenosine 5'-[gamma-thio]triphosphate
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Multiple sclerosis ( 31604244 ) Parkinson's disease ( 31660654 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Red blood cell count ( 32888494 )	Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Parkinson's disease ( 25064009 ) Systolic blood pressure ( 31928498 ) Triglyceride levels ( 31928498 ) Waist circumference ( 31928498 )
Novel Interactors		2 novel interactors: BCKDK TAOK2	10 novel interactors: BCKDHB CDIPT EIF3C FOXO1 GUCA1A PCDHB9 QPRT SETD1A TAOK2 ZNF267
Interacting Genes		5 interacting genes: DPY30 EP300 H3C1 H3C14 LBP	11 interacting genes: APP EPS8 FBXO7 FXR1 FXR2 LSM8 NR5A2 SPTA1 STAT3 TRAF4 UBC
Entrez ID		9739	10295
HPRD ID		13795	12523
Ensembl ID		ENSG00000099381	ENSG00000103507
Uniprot IDs		O15047	O14874
PDB IDs		3S8S 3UVN 4EWR 8ILY	8F5F 8F5J 8F5S 9DI9
GO Terms Enriched among Interactors		Positive Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Tau Protein Binding Chromatin Organization Epigenetic Regulation Of Gene Expression Peptidyl-lysine Propionylation Swimming Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Transcription Initiation-coupled Chromatin Remodeling Histone Butyryltransferase Activity Histone Crotonyltransferase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Structural Constituent Of Chromatin Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Regulation Of Glucose Metabolic Process Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Lipopolysaccharide Transport Nucleosome Assembly N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Nucleosome Nucleosome Organization Basal Dendrite Morphogenesis Basal Dendrite Arborization Negative Regulation Of Protein Oligomerization Catalytic Activity, Acting On A Protein Chromosome Isoleucine Metabolic Process L-isoleucine Catabolic Process Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity L-valine Catabolic Process L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Innate Immune Response-activating Signaling Pathway Lipoteichoic Acid Binding Protein-DNA Complex Assembly Valine Metabolic Process L-leucine Catabolic Process Positive Regulation Of TORC2 Signaling	Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Catabolic Process Regulation Of Developmental Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Stem Cell Differentiation Translation Regulator Activity Positive Regulation Of JNK Cascade Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of MRNA Catabolic Process Regulation Of Biological Quality Stem Cell Population Maintenance Maintenance Of Cell Number Ubiquitin Protein Ligase Binding Regulation Of MiRNA-mediated Gene Silencing Dentate Gyrus Development Positive Regulation Of Phosphate Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Cell Shape Regulation Of JNK Cascade Post-transcriptional Regulation Of Gene Expression Protein Heterodimerization Activity Actin Filament Capping Positive Regulation Of MRNA Metabolic Process Cytoplasmic Translational Initiation Amyloid-beta Complex Axon Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Actin Filament Depolymerization Temperature Homeostasis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Stress-activated MAPK Cascade Zygotic Genome Activation Positive Regulation Of Guanylate Cyclase Activity Presynaptic Modulation Of Chemical Synaptic Transmission