BCKDK and CDIPT

		BCKDK	CDIPT
Description		branched chain keto acid dehydrogenase kinase	CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Oxoglutarate Dehydrogenase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Protein Serine Kinase Activity Catalytic Activity, Acting On A Protein	CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Protein Binding Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Diacylglycerol Binding Manganese Ion Binding Carbohydrate Binding Alcohol Binding Metal Ion Binding
	Biological Process	L-isoleucine Catabolic Process L-leucine Catabolic Process L-valine Catabolic Process Spermatogenesis Lipid Biosynthetic Process Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phospholipid Biosynthetic Process CDP-diacylglycerol Metabolic Process
Pathways		Branched-chain amino acid catabolism Branched-chain ketoacid dehydrogenase kinase deficiency	Synthesis of PI
Drugs		Adenosine 5'-[gamma-thio]triphosphate	scyllo-inositol
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498)	Mean platelet volume ( 27863252)
Interacting Genes		11 interacting genes: APP EPS8 FBXO7 FXR1 FXR2 LSM8 NR5A2 SPTA1 STAT3 TRAF4 UBC	60 interacting genes: APP AQP2 AQP6 ARL13B ATP6V0E1 BSND CD79A CGRRF1 CISD2 CPLX4 CYB561 CYB5R3 DARS2 EBP ELOVL4 ERGIC3 EVI2B FAM209A FCER1G FCGR2A FFAR2 FKBP7 GJB1 GOLM1 GPR101 GPR151 GPR152 GPX8 HSD17B13 IER3IP1 IGFBP6 JAGN1 KCNK1 KIR2DL3 LNX1 MFF MGST3 MS4A14 MTIF3 ODF4 PLP1 PSCA RELL2 RETREG3 RNF19B RPLP1 RTN3 SCAI SCN3B SDCBP SIGLEC12 SLC10A1 SLC10A6 SLC16A7 SLC7A1 SSMEM1 TLCD4 TMX2 UNC93A VMA21
Entrez ID		10295	10423
HPRD ID		12523	12063
Ensembl ID		ENSG00000103507	ENSG00000103502
Uniprot IDs		O14874	A8K3L7 O14735
PDB IDs		8F5F 8F5J 8F5S 9DI9
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Catabolic Process Regulation Of Developmental Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Stem Cell Differentiation Translation Regulator Activity Positive Regulation Of JNK Cascade Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of MRNA Catabolic Process Regulation Of Biological Quality Stem Cell Population Maintenance Maintenance Of Cell Number Ubiquitin Protein Ligase Binding Regulation Of MiRNA-mediated Gene Silencing Dentate Gyrus Development Positive Regulation Of Phosphate Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Cell Shape Regulation Of JNK Cascade Post-transcriptional Regulation Of Gene Expression Protein Heterodimerization Activity Actin Filament Capping Positive Regulation Of MRNA Metabolic Process Cytoplasmic Translational Initiation Amyloid-beta Complex Axon Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Actin Filament Depolymerization Temperature Homeostasis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Stress-activated MAPK Cascade Zygotic Genome Activation Positive Regulation Of Guanylate Cyclase Activity Presynaptic Modulation Of Chemical Synaptic Transmission	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum Organization Plasma Membrane Identical Protein Binding Bile Acid:sodium Symporter Activity
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