HERPUD1 and AMFR

Number of citations of the paper that reports this interaction (PubMedID 21965653)
63

Data Source:
BioGRID (enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology)

		HERPUD1	AMFR
Description		homocysteine inducible ER protein with ubiquitin like domain 1	autocrine motility factor receptor
Image
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Lewy Body Core	Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Transmembrane Transporter Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Intracellular Calcium Ion Homeostasis Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress ERAD Pathway Protein Targeting To ER Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of ERAD Pathway Positive Regulation Of ERAD Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Canonical NF-kappaB Signal Transduction Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Non-canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress	N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Cardiovascular risk factors ( 20838585) Coronary artery disease ( 29212778) Diisocyanate-induced asthma ( 25918132) HDL cholesterol ( 20031564 23505323 24886709) HDL Cholesterol in HIV-infection ( 25884002) HDL cholesterol levels ( 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels in HIV infection ( 33109212) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 33339817) Hip circumference adjusted for BMI ( 34021172) Hypo-HDL-cholesterolemia ( 31087446) LDL cholesterol levels ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 33339817) Low HDL-cholesterol levels ( 31910446) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Serum metabolite levels ( 33031748) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 29403010 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)
Interacting Genes		19 interacting genes: AMFR APP ARHGDIA C5AR2 CCR2 CD3D CD58 CHRM2 EWSR1 F2RL1 IMPA2 PSEN1 RPA2 SH3RF1 STARD9 TOLLIP UBQLN2 USP7 XRCC6	32 interacting genes: BAG6 CRMP1 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 PPP1R13L RETREG1 SOD1 TAB3 TMCO1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP
Entrez ID		9709	267
HPRD ID		07456	09130
Ensembl ID		ENSG00000051108	ENSG00000159461
Uniprot IDs		A4UAE9 Q15011 Q53FP9	Q9UKV5
PDB IDs		1WGD	2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD 8T0S
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Signal Transduction Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Astrocyte Activation Involved In Immune Response Regulation Of Immune Response Regulation Of Tumor Necrosis Factor Production Regulation Of Proteolysis Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune System Process Regulation Of Chemotaxis Positive Regulation Of Protein Catabolic Process Positive Regulation Of Type II Interferon Production Immune System Process Positive Regulation Of Immune Response Regulation Of Proteasomal Protein Catabolic Process Neuron Projection Maintenance Regulation Of Leukocyte Migration Dendrite Protein-containing Complex Regulation Of Synaptic Vesicle Cycle Regulation Of Interleukin-8 Production Response To Stress Regulation Of Immune System Process Positive Regulation Of Leukocyte Chemotaxis Autophagosome Assembly Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Amyloid Fibril Formation Positive Regulation Of JNK Cascade Astrocyte Activation Regulation Of Cytokine Production Autophagosome Organization Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Superoxide Anion Generation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Catabolic Process Regulation Of Type II Interferon Production Positive Regulation Of Monocyte Chemotaxis Leukocyte Activation Positive Regulation Of Glycolytic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Myeloid Leukocyte Activation Early Endosome	Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteasomal Protein Catabolic Process ERAD Pathway Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein Protein Metabolic Process Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Retrograde Protein Transport, ER To Cytosol Cytosol Cellular Response To Stress Cellular Response To Topologically Incorrect Protein Macromolecule Metabolic Process Protein Exit From Endoplasmic Reticulum Protein K11-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of ERAD Pathway Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding ATP Binding Negative Regulation Of Signal Transduction BAT3 Complex Transferase Activity Protein K63-linked Ubiquitination Regulation Of ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process BAT3 Complex Binding Maintenance Of Unfolded Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?