GLA and GPR17

		GLA	GPR17
Description		galactosidase alpha	G protein-coupled receptor 17
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Receptor Serine/threonine Kinase Binding
	Biological Process	Carbohydrate Metabolic Process Lipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signal Transduction G Protein-coupled Receptor Signaling Pathway Oligodendrocyte Differentiation Chemokine-mediated Signaling Pathway
Pathways		Neutrophil degranulation Glycosphingolipid catabolism	Leukotriene receptors G alpha (q) signalling events P2Y receptors G alpha (i) signalling events
Drugs		Migalastat	Uridine diphosphate glucose Uridine-5'-Diphosphate Galactose-uridine-5'-diphosphate
Diseases		Fabry disease
GWAS			Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		3 interacting genes: OGT TERT UBC	2 interacting genes: GNA13 GPR37
Entrez ID		2717	2840
HPRD ID		02357	04351
Ensembl ID		ENSG00000102393	ENSG00000144230
Uniprot IDs		A0A3B3IUC4 A0A6Q8PHD1 P06280 Q53Y83	G4XH68 Q13304
PDB IDs		1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT 8K7D 8K7E 8K7F 8K7G 8K7H 8K7I 8K7J 8K7K 8K7L 9AVS	7Y89
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Prosaposin Receptor Activity D5 Dopamine Receptor Binding Glycosylceramide Catabolic Process Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Dopamine Metabolic Process Locomotion Involved In Locomotory Behavior Rho-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Oxidoreductase Activity Dopamine Biosynthetic Process Glycosylceramide Metabolic Process Glycosphingolipid Catabolic Process Glycolipid Catabolic Process Ceramide Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Oxidoreductase Activity Regulation Of Dopamine Metabolic Process Catecholamine Biosynthetic Process Neuropeptide Receptor Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Neuropeptide Binding Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Peptide Binding G Protein-coupled Receptor Signaling Pathway Amine Biosynthetic Process Biogenic Amine Biosynthetic Process Dopamine Metabolic Process Branching Involved In Blood Vessel Morphogenesis Heterotrimeric G-protein Complex Sphingolipid Catabolic Process G Protein-coupled Peptide Receptor Activity Membrane Lipid Catabolic Process Dendrite Development Catecholamine Metabolic Process Regulation Of Fibroblast Migration Regulation Of Postsynapse Assembly Hsp70 Protein Binding Glycosphingolipid Metabolic Process Brush Border Membrane Oligosaccharide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Biogenic Amine Metabolic Process Heat Shock Protein Binding Rho Protein Signal Transduction Platelet Activation
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