GLA and NAP1L3

		GLA	NAP1L3
Description		galactosidase alpha	nucleosome assembly protein 1 like 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity	Chromatin Binding Protein Binding Histone Binding
	Biological Process	Carbohydrate Metabolic Process Lipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	Nucleosome Assembly
Pathways		Neutrophil degranulation Glycosphingolipid catabolism
Drugs		Migalastat
Diseases		Fabry disease
GWAS			Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: OGT TERT UBC	3 interacting genes: BEND7 TSPYL4 USP25
Entrez ID		2717	4675
HPRD ID		02357	02123
Ensembl ID		ENSG00000102393	ENSG00000186310
Uniprot IDs		A0A3B3IUC4 A0A6Q8PHD1 P06280 Q53Y83	Q8IYV1 Q99457
PDB IDs		1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT 8K7D 8K7E 8K7F 8K7G 8K7H 8K7I 8K7J 8K7K 8K7L 9AVS
Enriched GO Terms of Interacting Partners?			Glycosylceramide Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Alpha-galactosidase Activity Negative Regulation Of Interleukin-17-mediated Signaling Pathway Ubiquitin-like Protein Peptidase Activity Interleukin-17A-mediated Signaling Pathway Negative Regulation Of ERAD Pathway Negative Regulation Of Oxidoreductase Activity Negative Regulation Of Response To Oxidative Stress SUMO Binding Glycosylceramide Metabolic Process Glycosphingolipid Catabolic Process Ceramide Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Oxidoreductase Activity Glycolipid Catabolic Process Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein K63-linked Deubiquitination Regulation Of ERAD Pathway Deubiquitinase Activity Protein K48-linked Deubiquitination Regulation Of Response To Oxidative Stress Sphingolipid Catabolic Process
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