GLA and NOSTRIN

		GLA	NOSTRIN
Description		galactosidase alpha	nitric oxide synthase trafficking
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity	DNA Binding Protein Binding
	Biological Process	Carbohydrate Metabolic Process Lipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	Endocytosis Signal Transduction Negative Regulation Of DNA-templated Transcription
Pathways		Neutrophil degranulation Glycosphingolipid catabolism	NOSTRIN mediated eNOS trafficking
Drugs		Migalastat
Diseases		Fabry disease
GWAS			Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil count ( 32888494) Granulocyte count ( 27863252) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Mitochondrial DNA levels ( 25240745) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		3 interacting genes: OGT TERT UBC	6 interacting genes: APC KDM1A MAGEA6 NOS3 PRMT6 TULP3
Entrez ID		2717	115677
HPRD ID		02357	06324
Ensembl ID		ENSG00000102393	ENSG00000163072
Uniprot IDs		A0A3B3IUC4 A0A6Q8PHD1 P06280 Q53Y83	Q8IVI9
PDB IDs		1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT 8K7D 8K7E 8K7F 8K7G 8K7H 8K7I 8K7J 8K7K 8K7L 9AVS	2YUN
Enriched GO Terms of Interacting Partners?			Endocardial Cushion Morphogenesis Regulation Of Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Smooth Muscle Hyperplasia Flavin Adenine Dinucleotide Binding Negative Regulation Of Muscle Hyperplasia Bronchus Morphogenesis Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Intraciliary Transport Particle A Binding Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Negative Regulation Of Signal Transduction Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Demethylase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Metabolic Process Glycosylceramide Catabolic Process Cadmium Ion Binding MRF Binding Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Localization To Centrosome Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Negative Regulation Of Oxidoreductase Activity Smooth Muscle Adaptation Regulation Of Systemic Arterial Blood Pressure By Endothelin L-arginine Catabolic Process Regulation Of The Force Of Heart Contraction By Chemical Signal Arginine Binding Embryonic Neurocranium Morphogenesis Response To Fungicide Histone H3K4 Demethylase Activity Guanine Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Ovulation From Ovarian Follicle Tetrahydrobiopterin Metabolic Process
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