GLA and GUCY2F

Data Source: HiPPIP (Novel)

		GLA	GUCY2F
Name		galactosidase alpha	guanylate cyclase 2F, retinal
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Nuclear Outer Membrane Plasma Membrane Membrane Cell Projection Photoreceptor Disc Membrane Rod Photoreceptor Outer Segment
	Molecular Function	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Signaling Receptor Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Carbohydrate Metabolic Process Lipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	CGMP Biosynthetic Process Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Regulation Of Opsin-mediated Signaling Pathway Intracellular Signal Transduction Detection Of Light Stimulus Involved In Visual Perception
Pathways		Neutrophil degranulation Glycosphingolipid catabolism	Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Migalastat	None
Diseases		Fabry disease	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		12 novel interactors: ANKRD30A CCR2 COL4A5 DUSP6 GPR17 GUCY2F HNRNPH2 MORF4L2 NAP1L3 NOSTRIN PDE6B PLP1	1 novel interactors: GLA
Interacting Genes		3 interacting genes: OGT TERT UBC	1 interacting genes: GUCA1B
Entrez ID		2717	2986
HPRD ID		02357	02078
Ensembl ID		ENSG00000102393	ENSG00000101890
Uniprot IDs		A0A3B3IUC4 A0A6Q8PHD1 P06280 Q53Y83	P51841
PDB IDs		1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT 8K7D 8K7E 8K7F 8K7G 8K7H 8K7I 8K7J 8K7K 8K7L 9AVS	Not available
GO Terms Enriched among Interactors		None	Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Guanylate Cyclase Regulator Activity Glycosylceramide Catabolic Process Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Cone Photoreceptor Outer Segment Calcium Sensitive Guanylate Cyclase Activator Activity Negative Regulation Of Oxidoreductase Activity Glycosylceramide Metabolic Process Glycosphingolipid Catabolic Process Glycolipid Catabolic Process Ceramide Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Oxidoreductase Activity Photoreceptor Disc Membrane Receptor Guanylyl Cyclase Signaling Pathway Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Sphingolipid Catabolic Process Phototransduction Membrane Lipid Catabolic Process Oligosaccharide Metabolic Process Glycosphingolipid Metabolic Process Photoreceptor Inner Segment Detection Of Light Stimulus Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Photoreceptor Outer Segment Hydrolase Activity, Acting On Glycosyl Bonds Body Fluid Secretion Glycolipid Metabolic Process Ceramide Metabolic Process Azurophil Granule Lumen Lysosomal Lumen Detection Of Abiotic Stimulus Sphingolipid Metabolic Process