CARTPT and MEIS2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CARTPT	MEIS2
Name		CART prepropeptide	Meis homeobox 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Synapse	Chromatin Nucleus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function Neuropeptide Hormone Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Intracellular Glucose Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Adult Feeding Behavior Cellular Response To Starvation Positive Regulation Of Cell Communication Negative Regulation Of Appetite Positive Regulation Of Epinephrine Secretion Circadian Regulation Of Gene Expression Response To Morphine Positive Regulation Of MAPK Cascade Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of Bone Resorption Regulation Of Bone Remodeling Regulation Of Insulin Secretion Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Biological Quality Negative Regulation Of Glucagon Secretion Somatostatin Secretion	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Regulation Of DNA-templated Transcription Brain Development Positive Regulation Of Cell Population Proliferation Visual Learning Response To Mechanical Stimulus Embryonic Pattern Specification Animal Organ Morphogenesis Pancreas Development Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Positive Regulation Of Cardiac Muscle Myoblast Proliferation
Drugs		Amphetamine	None
GWAS		No GWAS studies recorded	Angiotensin-converting enzyme inhibitor intolerance ( 28030426 ) Hyperactive-impulsive symptoms ( 18821565 ) Intraocular pressure ( 24002674 ) Major depressive disorder ( 27479909 ) Post bronchodilator FEV1 in COPD ( 26634245 ) Postprandial triglyceride response ( 32603185 ) Response to antipsychotic treatment ( 20195266 ) Restless legs syndrome ( 29029846 ) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014 )
Interacting Genes		4 interacting genes: CEACAM1 CEACAM6 MEIS2 SDHB	50 interacting genes: ADRA2C ANTKMT ANXA1 APP ARNT2 BPIFA1 C1orf94 CARTPT CCDC196 CTAG1A CTAG1B DGCR6 DRD1 FAM136A FAM168A HOXA13 HOXA9 IGFBP6 ITGB3BP KRTAP10-8 KRTAP11-1 KRTAP13-1 KRTAP19-2 KRTAP19-6 KRTAP22-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 MCCD1 NDUFB7 NOTO NUP58 OIP5 OSGIN1 PBX1 POU2AF1 POU6F2 PTK6 RBPMS RUSC1 SCT SPMIP6 SQSTM1 TBX2 TIMM10B TLX1 TRIM25 TRIM42 VGLL1 ZNHIT3
Entrez ID		9607	4212
HPRD ID		04006	03443
Ensembl ID		ENSG00000164326	ENSG00000134138
Uniprot IDs		Q16568	B3KPD8 B7Z6F6 O14770
PDB IDs		1HY9	3K2A 4XRM 5BNG 5EG0
GO Terms Enriched among Interactors		Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Insulin Receptor Internalization Negative Regulation Of Cytotoxic T Cell Degranulation Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cardiac Muscle Myoblast Proliferation Succinate Dehydrogenase (quinone) Activity 3 Iron, 4 Sulfur Cluster Binding Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Granulocyte Colony-stimulating Factor Signaling Pathway Insulin Catabolic Process Regulation Of Homophilic Cell Adhesion Mitochondrial Electron Transport, Succinate To Ubiquinone Respiratory Chain Complex II (succinate Dehydrogenase) Ubiquinone Binding Regulation Of Myeloid Cell Differentiation Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Succinate Metabolic Process Bile Acid Transmembrane Transporter Activity Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Granulocyte Differentiation Regulation Of Blood Vessel Remodeling Negative Regulation Of Platelet Aggregation	Intermediate Filament Positive Regulation Of Long-term Synaptic Potentiation