CARTPT and SDHB

Number of citations: 44 (PubMedID 17634068)
Data Source: BioGRID (pull down)

		CARTPT	SDHB
Name		CART prepropeptide	succinate dehydrogenase complex iron sulfur subunit B
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Synapse	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex II (succinate Dehydrogenase)
	Molecular Function	Molecular_function Neuropeptide Hormone Activity Protein Binding	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Ubiquinone Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Intracellular Glucose Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Adult Feeding Behavior Cellular Response To Starvation Positive Regulation Of Cell Communication Negative Regulation Of Appetite Positive Regulation Of Epinephrine Secretion Circadian Regulation Of Gene Expression Response To Morphine Positive Regulation Of MAPK Cascade Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of Bone Resorption Regulation Of Bone Remodeling Regulation Of Insulin Secretion Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Biological Quality Negative Regulation Of Glucagon Secretion Somatostatin Secretion	Tricarboxylic Acid Cycle Succinate Metabolic Process Mitochondrial Electron Transport, Succinate To Ubiquinone Aerobic Respiration Respiratory Electron Transport Chain Proton Motive Force-driven Mitochondrial ATP Synthesis
Pathways		None	Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle
Drugs		Amphetamine	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Height ( 20189936 ) Hip circumference adjusted for BMI ( 34021172 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		4 interacting genes: CEACAM1 CEACAM6 MEIS2 SDHB	8 interacting genes: ABCA1 CARTPT GEM MSRA PIK3R5 SPRY2 TMEM132D XRN1
Entrez ID		9607	6390
HPRD ID		04006	01707
Ensembl ID		ENSG00000164326	ENSG00000117118
Uniprot IDs		Q16568	A0AAQ5BHD9 P21912
PDB IDs		1HY9	7KCL 7KCM 7KLU 7KLV 8GS8
GO Terms Enriched among Interactors		Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Insulin Receptor Internalization Negative Regulation Of Cytotoxic T Cell Degranulation Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cardiac Muscle Myoblast Proliferation Succinate Dehydrogenase (quinone) Activity 3 Iron, 4 Sulfur Cluster Binding Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Granulocyte Colony-stimulating Factor Signaling Pathway Insulin Catabolic Process Regulation Of Homophilic Cell Adhesion Mitochondrial Electron Transport, Succinate To Ubiquinone Respiratory Chain Complex II (succinate Dehydrogenase) Ubiquinone Binding Regulation Of Myeloid Cell Differentiation Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Succinate Metabolic Process Bile Acid Transmembrane Transporter Activity Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Granulocyte Differentiation Regulation Of Blood Vessel Remodeling Negative Regulation Of Platelet Aggregation	Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction