ENTPD4 and RPS27

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ENTPD4	RPS27
Description		ectonucleoside triphosphate diphosphohydrolase 4	ribosomal protein S27
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Lysosome Lysosomal Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Postsynaptic Density Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Presynapse Glutamatergic Synapse GABA-ergic Synapse Ribonucleoprotein Complex
	Molecular Function	GTPase Activity GDP Phosphatase Activity Protein Binding Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity Ribonucleoside Triphosphate Phosphatase Activity CDP Phosphatase Activity CTPase Activity UDP Phosphatase Activity	DNA Binding RNA Binding Structural Constituent Of Ribosome Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	UDP Catabolic Process Purine Ribonucleotide Metabolic Process Pyrimidine Ribonucleotide Catabolic Process Nucleobase-containing Small Molecule Catabolic Process CTP Metabolic Process GDP Catabolic Process	Ribosomal Small Subunit Assembly Cytoplasmic Translation RRNA Processing Translation Ribosomal Small Subunit Biogenesis
Pathways		Phosphate bond hydrolysis by NTPDase proteins	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Major pathway of rRNA processing in the nucleolus and cytosol Mitotic Prometaphase Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency EML4 and NUDC in mitotic spindle formation SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Birth weight ( 31043758) Height ( 31562340) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Thyroid stimulating hormone levels ( 32769997)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		1 interacting genes: RPS27	16 interacting genes: ACTN1 ACTN4 APC ENOPH1 ENTPD4 MARS1 MRPS18C NACAD NSG2 PPBP PSME3 PTEN RTN4 SKIL TOM1 WDCP
Entrez ID		9583	6232
HPRD ID		09618	04744
Ensembl ID		ENSG00000197217	ENSG00000177954
Uniprot IDs		Q9Y227	P42677
PDB IDs		6WG5	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8RG0 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Synaptic Vesicle Recycling Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Serine/threonine Phosphatase Complex Presynapse Positive Regulation Of Calcium Ion Import Across Plasma Membrane Calmodulin-dependent Protein Phosphatase Activity Glutamatergic Synapse Calcineurin Complex Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Ribosomal Small Subunit Assembly Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Calcineurin-mediated Signaling Regulation Of Synaptic Vesicle Recycling Regulation Of Calcineurin-mediated Signaling Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcineurin-NFAT Signaling Cascade Cytosolic Small Ribosomal Subunit Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transport Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Small-subunit Processome Ribosomal Small Subunit Biogenesis Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Regulation Of Calcium-mediated Signaling Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Calcium Ion Transport Cytosolic Ribosome GABA-ergic Synapse Negative Regulation Of Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Cytoplasmic Translation Dephosphorylation Phosphoprotein Phosphatase Activity Regulation Of Calcium Ion Transmembrane Transport Structural Constituent Of Ribosome	Platelet Alpha Granule Lumen Cell Junction Pseudopodium
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