COL15A1

Description		collagen type XV alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type XV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Angiogenesis Cell Adhesion Signal Transduction Cell Differentiation
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Appendicular lean mass ( 33097823) Asthma ( 32296059 31959851) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Epithelial ovarian cancer ( 25134534) Fractures (paediatric) ( 32742401) Gut microbiota alpha diversity (Shannon index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Height ( 28552196) Lateral ventricle temporal horn volume ( 31530798) Pulse pressure ( 30224653 30578418) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		6 novel interacting genes: GAS1 GOLGA5 GTF2IRD1 MYO9A PDGFB PIGO
Interacting Genes
Entrez ID		1306
HPRD ID		00380
Ensembl ID		ENSG00000204291
Uniprot IDs		B3KTP7 P39059
PDB IDs		3N3F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metanephric Mesenchymal Cell Migration Cellular Response To Mycophenolic Acid Metanephric Glomerular Mesangial Cell Development Platelet-derived Growth Factor Complex Positive Regulation Of Glomerular Filtration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Transition Between Slow And Fast Fiber Mannose-ethanolamine Phosphotransferase Activity Glomerular Mesangial Cell Development Unconventional Myosin Complex Smooth Muscle Adaptation Negative Regulation Of Phospholipid Biosynthetic Process Regulation Of Hyaluronan Biosynthetic Process Mesangial Cell Development Positive Regulation Of Glomerular Mesangial Cell Proliferation Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Protein Autophosphorylation Paracrine Signaling Cellular Response To Growth Factor Stimulus Regulation Of ER To Golgi Vesicle-mediated Transport Platelet-derived Growth Factor Binding Regulation Of Glomerular Mesangial Cell Proliferation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Superoxide-generating NADPH Oxidase Activator Activity Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Glomerular Filtration Regulation Of Skeletal Muscle Adaptation Golgi Cisterna Retrograde Transport, Vesicle Recycling Within Golgi Phosphotransferase Activity, For Other Substituted Phosphate Groups Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
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