COL15A1 and GAS1

		COL15A1	GAS1
Description		collagen type XV alpha 1 chain	growth arrest specific 1
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type XV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Extracellular Exosome	Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength	Protein Binding Oxysterol Binding
	Biological Process	Angiogenesis Cell Adhesion Signal Transduction Cell Differentiation	Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Processing Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Mitotic Cell Cycle Developmental Growth Regulation Of Cell Cycle Regulation Of ER To Golgi Vesicle-mediated Transport
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization	Ligand-receptor interactions Activation of SMO
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Appendicular lean mass ( 33097823) Asthma ( 32296059 31959851) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Epithelial ovarian cancer ( 25134534) Fractures (paediatric) ( 32742401) Gut microbiota alpha diversity (Shannon index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Height ( 28552196) Lateral ventricle temporal horn volume ( 31530798) Pulse pressure ( 30224653 30578418) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Heel bone mineral density ( 30598549) Insulin resistance/response ( 21901158) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes			5 interacting genes: BIRC2 DLK1 ERRFI1 PTPRA SHH
Entrez ID		1306	2619
HPRD ID		00380	00747
Ensembl ID		ENSG00000204291	ENSG00000180447
Uniprot IDs		B3KTP7 P39059	P54826
PDB IDs		3N3F	7RHQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metanephric Mesenchymal Cell Migration Cellular Response To Mycophenolic Acid Metanephric Glomerular Mesangial Cell Development Platelet-derived Growth Factor Complex Positive Regulation Of Glomerular Filtration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Transition Between Slow And Fast Fiber Mannose-ethanolamine Phosphotransferase Activity Glomerular Mesangial Cell Development Unconventional Myosin Complex Smooth Muscle Adaptation Negative Regulation Of Phospholipid Biosynthetic Process Regulation Of Hyaluronan Biosynthetic Process Mesangial Cell Development Positive Regulation Of Glomerular Mesangial Cell Proliferation Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Protein Autophosphorylation Paracrine Signaling Cellular Response To Growth Factor Stimulus Regulation Of ER To Golgi Vesicle-mediated Transport Platelet-derived Growth Factor Binding Regulation Of Glomerular Mesangial Cell Proliferation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Superoxide-generating NADPH Oxidase Activator Activity Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Glomerular Filtration Regulation Of Skeletal Muscle Adaptation Golgi Cisterna Retrograde Transport, Vesicle Recycling Within Golgi Phosphotransferase Activity, For Other Substituted Phosphate Groups Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation	Lung Epithelium Development Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Collagen Type XV Trimer Steroid Metabolic Process Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Skin Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Left Lung Development Positive Regulation Of Sclerotome Development Right Lung Development Vasculature Development Polarity Specification Of Anterior/posterior Axis Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Primary Prostatic Bud Elongation Tracheoesophageal Septum Formation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Protein K48-linked Ubiquitination FBXO Family Protein Binding Nitric-oxide Synthase Complex Cholesterol Metabolic Process Sterol Metabolic Process Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Intein-mediated Protein Splicing Cholesterol-protein Transferase Activity Prostate Epithelial Cord Elongation Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Skeletal Muscle Cell Proliferation Bud Outgrowth Involved In Lung Branching Ventral Midline Development Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Specification Of Axis Polarity Trachea Morphogenesis Trachea Development Negative Regulation Of Dopaminergic Neuron Differentiation Hindgut Morphogenesis Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Positive Regulation Of Protein Monoubiquitination Nitrite Reductase (NO-forming) Activity Salivary Gland Cavitation Mesenchymal Cell Proliferation Involved In Lung Development Epithelial-mesenchymal Cell Signaling Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Trunk Neural Crest Cell Migration
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