COL15A1 and PIGO

		COL15A1	PIGO
Description		collagen type XV alpha 1 chain	phosphatidylinositol glycan anchor biosynthesis class O
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type XV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength	Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Phosphotransferase Activity, For Other Substituted Phosphate Groups Mannose-ethanolamine Phosphotransferase Activity
	Biological Process	Angiogenesis Cell Adhesion Signal Transduction Cell Differentiation	GPI Anchor Biosynthetic Process
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Appendicular lean mass ( 33097823) Asthma ( 32296059 31959851) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Epithelial ovarian cancer ( 25134534) Fractures (paediatric) ( 32742401) Gut microbiota alpha diversity (Shannon index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Height ( 28552196) Lateral ventricle temporal horn volume ( 31530798) Pulse pressure ( 30224653 30578418) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Response to quetiapine in schizophrenia ( 29503163) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes			2 interacting genes: APP PIGF
Entrez ID		1306	84720
HPRD ID		00380	15134
Ensembl ID		ENSG00000204291	ENSG00000165282
Uniprot IDs		B3KTP7 P39059	Q8TEQ8
PDB IDs		3N3F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metanephric Mesenchymal Cell Migration Cellular Response To Mycophenolic Acid Metanephric Glomerular Mesangial Cell Development Platelet-derived Growth Factor Complex Positive Regulation Of Glomerular Filtration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Transition Between Slow And Fast Fiber Mannose-ethanolamine Phosphotransferase Activity Glomerular Mesangial Cell Development Unconventional Myosin Complex Smooth Muscle Adaptation Negative Regulation Of Phospholipid Biosynthetic Process Regulation Of Hyaluronan Biosynthetic Process Mesangial Cell Development Positive Regulation Of Glomerular Mesangial Cell Proliferation Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Protein Autophosphorylation Paracrine Signaling Cellular Response To Growth Factor Stimulus Regulation Of ER To Golgi Vesicle-mediated Transport Platelet-derived Growth Factor Binding Regulation Of Glomerular Mesangial Cell Proliferation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Superoxide-generating NADPH Oxidase Activator Activity Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Glomerular Filtration Regulation Of Skeletal Muscle Adaptation Golgi Cisterna Retrograde Transport, Vesicle Recycling Within Golgi Phosphotransferase Activity, For Other Substituted Phosphate Groups Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Perinuclear Region Of Cytoplasm Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Low-density Lipoprotein Particle Mediated Signaling Collagen Type XV Trimer Phosphorylase Kinase Complex Phosphorylase Kinase Activity Positive Regulation Of Glycogen Catabolic Process Ethanolaminephosphotransferase Activity Microtubule-based Process Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Regulation Of Glycogen Catabolic Process Peptidase Activator Activity Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen
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