ZFYVE19 and CAPN7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ZFYVE19	CAPN7
Description		zinc finger FYVE-type containing 19	calpain 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Midbody Cleavage Furrow Flemming Body	Nucleus Centrosome Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Metal Ion Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity MIT Domain Binding
	Biological Process	Negative Regulation Of Cytokinesis Mitotic Cytokinesis Checkpoint Signaling Cell Division Midbody Abscission	Proteolysis Positive Regulation Of Epithelial Cell Migration Self Proteolysis
Pathways			Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Malaria ( 31844061)	Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: AXIN1 CAPN7 CCHCR1 DPY30 HTT MITD1 TRIM55 TRIM63 VPS4B ZDHHC17	19 interacting genes: ARNT2 AXIN2 CEP63 CTBP2 GOLGA2 IFT88 IST1 MAD1L1 MAGED1 MDM4 PPP1R13B PRPSAP1 TNFAIP1 TRIM27 UBL7 VHL ZBTB9 ZFYVE19 ZNF655
Entrez ID		84936	23473
HPRD ID		15731	05908
Ensembl ID		ENSG00000166140	ENSG00000131375
Uniprot IDs		Q96K21	Q7Z479 Q9Y6W3
PDB IDs			2QFE 8UC6
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Mitotic Cytokinetic Process Viral Budding Viral Budding Via Host ESCRT Complex Midbody Abscission Cytokinetic Process Intracellular Transport Multivesicular Body Sorting Pathway P53 Binding Cellular Localization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Localization In Cell Beta-catenin Destruction Complex Assembly Axial Mesoderm Formation Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Organelle Assembly Canonical Wnt Signaling Pathway Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of CAMKK-AMPK Signaling Cascade MIT Domain Binding	Negative Regulation Of Cell Population Proliferation Identical Protein Binding Cell Division Negative Regulation Of Catabolic Process Regulation Of Cell Cycle Centrosome Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cytoplasm Ubiquitin-protein Transferase Activity Negative Regulation Of Autophagy Atrioventricular Valve Morphogenesis Negative Regulation Of Cell Cycle Process Midbody Abscission Regulation Of Primary Metabolic Process Mitotic Cytokinetic Process Mitotic Spindle Protein Ubiquitination Flemming Body Spindle Pole Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cytokinetic Process Regulation Of Cell Cycle Process Molecular Adaptor Activity MAD1 Complex Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Heart Valve Morphogenesis Proteasomal Protein Catabolic Process Post-translational Protein Modification Transcription Repressor Complex Protein Stabilization Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
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