SPTLC2 and NOTCH3

Number of citations of the paper that reports this interaction (PMID 25356737)
0

Data Source:
BioGRID (pull down)

		SPTLC2	NOTCH3
Gene Name		serine palmitoyltransferase, long chain base subunit 2	notch 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Integral Component Of Membrane Serine C-palmitoyltransferase Complex	Golgi Membrane Extracellular Region Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Receptor Complex
	Molecular Function	Serine C-palmitoyltransferase Activity Pyridoxal Phosphate Binding	Calcium Ion Binding Protein Binding Enzyme Binding
	Biological Process	Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Sphinganine Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Notch Receptor Processing Gene Expression Forebrain Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Glomerular Capillary Formation
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis	Notch-HLH transcription pathway Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing Signaling by NOTCH3
Drugs		Pyridoxal Phosphate L-Serine
Diseases
GWAS
Protein-Protein Interactions		2 interactors: NOTCH3 SPTLC1	40 interactors: BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B MAML1 MAML2 MAML3 MPPED2 MYC NEDD9 PPIA PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8
Entrez ID		9517	4854
HPRD ID		05755	02607
Ensembl ID		ENSG00000100596	ENSG00000074181
Uniprot IDs		O15270	Q9UM47
PDB IDs
Enriched GO Terms of Interacting Partners?		Sphinganine Biosynthetic Process Sphinganine Metabolic Process Sphingomyelin Biosynthetic Process Sphingosine Biosynthetic Process Sphingoid Biosynthetic Process Glomerular Capillary Formation Sphingosine Metabolic Process Sphingomyelin Metabolic Process Glomerulus Morphogenesis Notch Receptor Processing Glomerulus Vasculature Development Ceramide Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Glomerulus Development Sphingolipid Biosynthetic Process Neuron Fate Commitment Ceramide Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Cellular Biogenic Amine Metabolic Process Notch Signaling Pathway Amine Metabolic Process Nephron Development Sphingolipid Metabolic Process Transcription Initiation From RNA Polymerase II Promoter	Notch Signaling Pathway Notch Receptor Processing Transcription Initiation From RNA Polymerase II Promoter Tissue Morphogenesis DNA-templated Transcription, Initiation Morphogenesis Of An Epithelium Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Epithelium Development Positive Regulation Of Metabolic Process Immune System Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression System Development Positive Regulation Of Cellular Biosynthetic Process Multicellular Organismal Development Hemopoiesis Cell Surface Receptor Signaling Pathway Anatomical Structure Development Cell Fate Commitment Developmental Process Tube Development Positive Regulation Of Signal Transduction Cell Differentiation Regulation Of Cell Differentiation Organ Morphogenesis Auditory Receptor Cell Differentiation Heart Morphogenesis Epithelial Tube Morphogenesis Membrane Protein Proteolysis Myeloid Leukocyte Differentiation Positive Regulation Of Transcription Of Notch Receptor Target Hair Cell Differentiation Auditory Receptor Cell Fate Commitment Stem Cell Development Tube Morphogenesis Myoblast Differentiation Cell Development Endothelial Tube Morphogenesis Generation Of Neurons Notch Signaling Involved In Heart Development Amyloid Precursor Protein Catabolic Process Nervous System Development Stem Cell Maintenance Negative Regulation Of Cell Differentiation Stem Cell Differentiation Inner Ear Receptor Cell Differentiation
Tagcloud ?		a2 annexin attracted boyden cd74 cdk5 chamber chemotactic clues col11a1 f3 glioblastoma glioma gliomas gliotropism harbor histologically migrate mobile pd98057 proteomics prove reach rescovitine throughput timp tnfsf8 tropism u87	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
Tagcloud (Difference) ?		a2 annexin attracted boyden cd74 cdk5 chamber chemotactic clues col11a1 f3 glioblastoma glioma gliomas gliotropism harbor histologically migrate mobile pd98057 proteomics prove reach rescovitine throughput timp tnfsf8 tropism u87	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
Tagcloud (Intersection) ?