SPTLC2

Description		serine palmitoyltransferase long chain base subunit 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex
	Molecular Function	Serine C-palmitoyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Sphinganine Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Adipose Tissue Development Positive Regulation Of Lipophagy
Pathways		Sphingolipid de novo biosynthesis
Drugs		Pyridoxal phosphate Serine
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Red cell distribution width ( 32888494)
Interacting Genes		2 interacting genes: NOTCH3 SPTLC1
Entrez ID		9517
HPRD ID		05755
Ensembl ID		ENSG00000100596
Uniprot IDs		O15270
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q 7YIU 7YIY 7YJ1 7YJ2
Enriched GO Terms of Interacting Partners?		Sphinganine Biosynthetic Process Regulation Of Fat Cell Apoptotic Process Sphinganine Metabolic Process Glomerular Capillary Formation Neuroblast Differentiation Serine Palmitoyltransferase Complex Positive Regulation Of Lipophagy Serine C-palmitoyltransferase Activity Sphingosine Biosynthetic Process Sphingomyelin Biosynthetic Process Sphingoid Biosynthetic Process Sphingosine Metabolic Process Sphingomyelin Metabolic Process Diol Metabolic Process Endoplasmic Reticulum Membrane Neuron Fate Commitment Pyridoxal Phosphate Binding Positive Regulation Of MiRNA Transcription Ceramide Biosynthetic Process Artery Morphogenesis Positive Regulation Of MiRNA Metabolic Process Forebrain Development Negative Regulation Of Neuron Differentiation Regulation Of MiRNA Transcription Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of MiRNA Metabolic Process Ceramide Metabolic Process Positive Regulation Of Macroautophagy Sphingolipid Biosynthetic Process Blood Vessel Morphogenesis
Tagcloud ?