LITAF and PLOD2

Data Source: HiPPIP (Novel)

		LITAF	PLOD2
Name		lipopolysaccharide induced TNF factor	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Golgi Apparatus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Cytoplasmic Side Of Early Endosome Membrane Cytoplasmic Side Of Late Endosome Membrane Cytoplasmic Side Of Lysosomal Membrane	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Rough Endoplasmic Reticulum Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding WW Domain Binding	Iron Ion Binding Procollagen-lysine 5-dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Regulation Of Cytokine Production Regulation Of Macrophage Cytokine Production Response To Lipopolysaccharide Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of Non-canonical NF-kappaB Signal Transduction	Response To Hypoxia Protein O-linked Glycosylation Peptidyl-lysine Hydroxylation Collagen Fibril Organization Protein Modification Process Hydroxylysine Biosynthetic Process
Pathways		None	Collagen biosynthesis and modifying enzymes
Drugs		None	Ascorbic acid
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Bruck syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Colorectal or endometrial cancer ( 26621817 ) Crohn's disease ( 28067908 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Gallstone disease ( 30504769 ) Heel bone mineral density ( 30598549 ) Hip index ( 34021172 ) Inflammatory bowel disease ( 23128233 28067908 ) LDL cholesterol levels ( 32203549 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 33339817 32154731 ) Monocyte percentage of white cells ( 32888494 ) QT interval ( 19305409 30679814 29874175 29213071 24952745 23166209 19305408 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 ) TPE interval (resting) ( 32386560 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Height ( 31562340 ) Obesity-related traits ( 23251661 ) Squamous cell lung carcinoma ( 28604730 ) Zinc levels ( 26025379 )
Novel Interactors		1 novel interactors: PLOD2	6 novel interactors: CENPF CLSTN2 LITAF LYPLA1 NUCB1 WWTR1
Interacting Genes		42 interacting genes: ARID5A ATXN1 BAG3 CALCOCO2 COMT CREB5 DAZAP2 EPN1 EPN2 EPN3 GGA3 HGS HIP1 HPCAL1 HPCAL4 ITCH KCNIP1 KCNIP4 N4BP1 NCALD NEDD4 OPTN POGZ RADIL RASSF3 REEP6 RNF208 RPS27A SMAD2 STAM2 STAT6 TAX1BP1 TNIP1 TNIP3 TOM1 UBA52 UBQLN1 UBQLN2 VENTX VSNL1 WWOX ZIC1	1 interacting genes: LINC01554
Entrez ID		9516	5352
HPRD ID		10354	03519
Ensembl ID		ENSG00000189067	ENSG00000152952
Uniprot IDs		Q99732	A0A994J6S5 O00469
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Clathrin Binding Polyubiquitin Modification-dependent Protein Binding Cytosol Ubiquitin Binding Regulation Of Macroautophagy Autophagy Clathrin Vesicle Coat Autophagosome Regulation Of Signal Transduction Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol Binding Positive Regulation Of Catabolic Process Endocytosis Vesicle-mediated Transport Establishment Of Protein Localization To Vacuole ESCRT-0 Complex Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Cytoplasm Cytoplasmic Vesicle Regulation Of Protein Catabolic Process Regulation Of Autophagy Macroautophagy Protein Targeting To Lysosome Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Vacuole Endosome Positive Regulation Of Macroautophagy Positive Regulation Of Autophagosome Maturation Import Into Cell Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Early Endosome Membrane Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phospholipid Binding Protein Transport Protein Targeting To Vacuole Regulation Of Protein Deubiquitination Protein Binding Protein Localization To Lysosome Positive Regulation Of Nucleocytoplasmic Transport Protein-containing Complex Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transmembrane Transport Protein Tag Activity Regulation Of Autophagosome Maturation	None