FOXP4 and FOXP2

Number of citations of the paper that reports this interaction (PMID 14701752)
56

Data Source:
HPRD (in vitro, two hybrid)

		FOXP4	FOXP2
Gene Name		forkhead box P4	forkhead box P2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Heart Development Embryonic Foregut Morphogenesis Lung Secretory Cell Differentiation Negative Regulation Of Lung Goblet Cell Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesenchymal Cell Proliferation Transcription, DNA-templated Skeletal Muscle Tissue Development Post-embryonic Development Cerebellum Development Caudate Nucleus Development Putamen Development Cerebral Cortex Development Growth Vocal Learning Camera-type Eye Development Negative Regulation Of Transcription, DNA-templated Lung Alveolus Development Smooth Muscle Tissue Development Righting Reflex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 20676098)	Crohn's disease ( 22936669)
Protein-Protein Interactions		2 interactors: FOXP1 FOXP2	13 interactors: AES CCNC CTBP1 CTBP2 FAM124A FOXP1 FOXP4 MAPK3 PIN1 RPIA SDCBP SP4 TSACC
Entrez ID		116113	93986
HPRD ID		10600	05611
Ensembl ID		ENSG00000137166	ENSG00000128573
Uniprot IDs		Q8IVH2	B7ZLK5 O15409 Q8N6B5 Q8N6B6
PDB IDs			2A07 2AS5
Enriched GO Terms of Interacting Partners?		Smooth Muscle Tissue Development Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Stem Cell Proliferation Regulation Of Stem Cell Proliferation Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Positive Regulation Of Epithelial Cell Proliferation Interleukin-21 Secretion Putamen Development Caudate Nucleus Development Lung Development Respiratory Tube Development Muscle Organ Development Respiratory System Development Regulation Of Epithelial Cell Proliferation Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Lung Goblet Cell Differentiation Chemokine (C-C Motif) Ligand 2 Secretion Striated Muscle Tissue Development Muscle Tissue Development Chemokine Secretion Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Interleukin-12 Secretion T Follicular Helper Cell Differentiation Vocal Learning Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Muscle Structure Development Righting Reflex Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Monocyte Activation Immunoglobulin V(D)J Recombination Osteoclast Development Chemokine Production Auditory Behavior Regulation Of Defense Response To Bacterium Pre-B Cell Differentiation Negative Regulation Of B Cell Apoptotic Process Tube Development Endothelial Cell Activation Immature B Cell Differentiation Lung Secretory Cell Differentiation Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Monocyte Differentiation Positive Regulation Of Cell Proliferation Striatum Development Transcription From RNA Polymerase II Promoter Mechanosensory Behavior Positive Regulation Of Cardiac Muscle Cell Differentiation	Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Lung Goblet Cell Differentiation Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Lung Secretory Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter White Fat Cell Differentiation Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Viral Genome Replication Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Binding Negative Regulation Of Biosynthetic Process Regulation Of Histone Acetylation Positive Regulation Of Metabolic Process Biosynthetic Process Negative Regulation Of Protein Binding Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Lung Epithelial Cell Differentiation Lung Cell Differentiation Lung Epithelium Development Interleukin-21 Secretion Negative Regulation Of Apolipoprotein Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Positive Regulation Of Histone Modification Regulation Of Organelle Organization Axon Guidance Regulation Of Signal Transduction Response To Interleukin-1 Positive Regulation Of Organelle Organization
Tagcloud ?		ahcy arrays bac balanced breakpoints breaks ctcf dismissed ep300 fusions hcc1187 hcc1806 hybridized idea mapped microarrays oligonucleotide painting participating path pkd1l1 plausible reciprocal rif1 tax1bp1 tiling translocations unbalanced zr	20p12 21q22 22q13 42e 6p21 7q31 aif1 ancestry cd crohn cumulative ep300 european exerted genotyped gwas ifngr2 intergenic likelihood loci macrod2 rbx1 representing rs4820425 southern spain suggestive top undiscovered
Tagcloud (Difference) ?		ahcy arrays bac balanced breakpoints breaks ctcf dismissed fusions hcc1187 hcc1806 hybridized idea mapped microarrays oligonucleotide painting participating path pkd1l1 plausible reciprocal rif1 tax1bp1 tiling translocations unbalanced zr	20p12 21q22 22q13 42e 6p21 7q31 aif1 ancestry cd crohn cumulative european exerted genotyped gwas ifngr2 intergenic likelihood loci macrod2 rbx1 representing rs4820425 southern spain suggestive top undiscovered
Tagcloud (Intersection) ?		ep300