APOA2 and CATSPER1

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		APOA2	CATSPER1
Description		apolipoprotein A2	cation channel sperm associated 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Exosome Blood Microparticle	Plasma Membrane Cilium Membrane Motile Cilium Monoatomic Ion Channel Complex Sperm Flagellum CatSper Complex Cell Projection Sperm Principal Piece
	Molecular Function	Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity	Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Involved In Immune Response Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Lipid Transport Signal Transduction Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Positive Regulation Of Interleukin-8 Production Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Diacylglycerol Catabolic Process Positive Regulation Of Phagocytosis Protein Stabilization Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta	Monoatomic Ion Transport Calcium Ion Transport Spermatogenesis Cell Differentiation Flagellated Sperm Motility Monoatomic Ion Transmembrane Transport Transmembrane Transport Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Calcium Ion Transmembrane Transport
Pathways		PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport	Sperm Motility And Taxes
Drugs		Zinc Copper Zinc acetate	Bisphenol A diglycidyl ether
Diseases		Familial amyloidosis
GWAS			Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340)
Interacting Genes		31 interacting genes: ABCA13 APOC1 APOD APOF AQP6 C4A CATSPER1 CIAO2A CREB3 CYBC1 GET1 GJA8 HSD17B13 KIR2DL3 LMNA MUC1 NAXE NDRG1 PANX1 PDZK1IP1 PLTP PSCA SCARB1 SLC7A1 SSMEM1 STOM TAB1 TMEM45A TMEM82 TREM2 VKORC1	119 interacting genes: ABLIM3 ADAMTSL4 AGR2 AGR3 AJUBA AKAP8L APOA2 ARID5A BEGAIN C11orf16 CARD10 CDPF1 CFAP68 CHIC2 CHRD CPSF7 CTBP2 CYSRT1 EFEMP2 EMD EYA2 FHL5 FRS3 FST GLI1 HNRNPH1 HOXA1 IKZF3 KHDRBS2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1D LCE1E LCE1F LCE2C LCE5A LIMS1 LZTS2 MDFI MTUS2 MYCL NBPF19 NOTCH2NLA PAK5 PDLIM7 PLA2G10 PLAGL2 PLSCR1 PLSCR3 PMF1-BGLAP PTPN21 RFX6 RGS19 RGS20 RIMBP3 RSPO2 SAXO4 SCRG1 SIVA1 SORBS3 SPMIP6 SPRY2 SPRY3 SSC4D TGFB1 TNS2 TRAF2 TRIM27 TRIM42 TRIM8 TRIP6 TSPAN4 VWC2 ZBTB42 ZIM2 ZNF688 ZNF774 ZNF837
Entrez ID		336	117144
HPRD ID		00129	09396
Ensembl ID		ENSG00000158874	ENSG00000175294
Uniprot IDs		P02652	Q8NEC5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cholesterol Transport Lipid Transport High-density Lipoprotein Particle Binding Low-density Lipoprotein Particle Binding Regulation Of Lipid Transport High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Regulation Of Phosphatidylcholine Catabolic Process Lipid Transporter Activity Sterol Transport Respiratory Burst After Phagocytosis Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Detection Of Lipopolysaccharide Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Regulation Of Phospholipid Catabolic Process Regulation Of Cholesterol Efflux Monoatomic Anion Channel Activity Positive Regulation Of Apoptotic Cell Clearance Respiratory Burst Involved In Defense Response Organophosphate Ester Transport Regulation Of Phosphatidylcholine Metabolic Process Regulation Of Apoptotic Cell Clearance Organic Hydroxy Compound Transport Cholesterol Transport Endoplasmic Reticulum Regulation Of Endocytosis Detection Of Molecule Of Bacterial Origin Phagocytosis, Recognition Kinase Activator Activity Regulation Of Lipid Metabolic Process Phosphatidylethanolamine Binding Regulation Of Transport Carbohydrate Derivative Transport Apolipoprotein Binding Ceramide Transport Positive Regulation Of Lipid Transport Membrane Phospholipid Transport Gap Junction Channel Activity Respiratory Burst Regulation Of Phagocytosis Gap Junction Plasma Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Efflux Cholesterol Metabolic Process Sterol Metabolic Process	Intermediate Filament Keratin Filament Keratinization Epidermis Development Identical Protein Binding Hair Cycle Protein Binding Cytosol Lead Ion Binding Lung Growth Mercury Ion Binding
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