APOA2 and TREM2

Number of citations of the paper that reports this interaction (PubMedID 27477018)
0

Data Source:
BioGRID (pull down)

		APOA2	TREM2
Description		apolipoprotein A2	triggering receptor expressed on myeloid cells 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Exosome Blood Microparticle	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Plasma Membrane Raft
	Molecular Function	Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity	Lipopolysaccharide Binding Amyloid-beta Binding Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Protein Binding Phospholipid Binding Beta-catenin Binding High-density Lipoprotein Particle Binding Lipid Binding Phosphatidylethanolamine Binding Semaphorin Receptor Activity Kinase Activator Activity Low-density Lipoprotein Particle Binding Semaphorin Receptor Binding Apolipoprotein Binding Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Signaling Receptor Activity Peptidoglycan Binding Protein-containing Complex Binding Lipoteichoic Acid Binding Lipoprotein Particle Binding Scaffold Protein Binding Carbohydrate Derivative Binding Sulfatide Binding Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Cytokine Production Involved In Immune Response Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Lipid Transport Signal Transduction Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Positive Regulation Of Interleukin-8 Production Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Diacylglycerol Catabolic Process Positive Regulation Of Phagocytosis Protein Stabilization Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta	Microglial Cell Activation Microglial Cell Activation Involved In Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of Inflammatory Response To Antigenic Stimulus Response To Ischemia Phagocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Humoral Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Memory Regulation Of Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Negative Regulation Of Triglyceride Storage Positive Regulation Of High-density Lipoprotein Particle Clearance Regulation Of Lipid Metabolic Process Osteoclast Differentiation Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Detection Of Lipopolysaccharide Detection Of Peptidoglycan Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 6 Signaling Pathway Positive Regulation Of Macrophage Fusion Negative Regulation Of Glial Cell Apoptotic Process Social Behavior CXCL12-activated CXCR4 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Potassium Ion Transport Apoptotic Cell Clearance Regulation Of Innate Immune Response Positive Regulation Of Osteoclast Differentiation Respiratory Burst After Phagocytosis Positive Regulation Of Complement Activation, Classical Pathway Astrocyte Activation Cell Development Response To Axon Injury Positive Regulation Of Protein Secretion Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Activation Positive Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lipid Homeostasis Regulation Of Resting Membrane Potential Positive Regulation Of Phagocytosis, Engulfment Microglial Cell Proliferation Negative Regulation Of Astrocyte Activation Regulation Of Biological Quality Pyroptotic Inflammatory Response Negative Regulation Of Fat Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Detection Of Lipoteichoic Acid Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Glucose Stimulus Cellular Response To Lipid Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Hypoxia Semaphorin-plexin Signaling Pathway Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Regulation Of Primary Metabolic Process Dendritic Cell Differentiation Dendritic Spine Maintenance Amyloid-beta Clearance Import Into Cell Regulation Of Hippocampal Neuron Apoptotic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Complement-mediated Synapse Pruning Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Amyloid-beta Clearance By Cellular Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of P38MAPK Cascade Positive Regulation Of Microglial Cell Activation Negative Regulation Of Autophagic Cell Death Positive Regulation Of Microglial Cell Migration Cellular Response To Amyloid-beta Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Low-density Lipoprotein Particle Clearance Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of ATP Biosynthetic Process
Pathways		PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Other semaphorin interactions
Drugs		Zinc Copper Zinc acetate
Diseases		Familial amyloidosis	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS			Alzheimer's disease ( 23150908) Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood protein levels ( 30072576) C-reactive protein ( 22939635) Family history of Alzheimer's disease ( 30617256) Supraventricular ectopy ( 29618737)
Interacting Genes		31 interacting genes: ABCA13 APOC1 APOD APOF AQP6 C4A CATSPER1 CIAO2A CREB3 CYBC1 GET1 GJA8 HSD17B13 KIR2DL3 LMNA MUC1 NAXE NDRG1 PANX1 PDZK1IP1 PLTP PSCA SCARB1 SLC7A1 SSMEM1 STOM TAB1 TMEM45A TMEM82 TREM2 VKORC1	10 interacting genes: APOA1 APOA2 APOB APOE CLU GH1 NRN1L SCGB2A2 TYROBP UNC5B
Entrez ID		336	54209
HPRD ID		00129	05473
Ensembl ID		ENSG00000158874	ENSG00000095970
Uniprot IDs		P02652	Q5TCX1 Q9NZC2
PDB IDs			5ELI 5UD7 5UD8 6B8O 6XDS 6Y6C 6YMQ 6YYE 6Z0G 6Z0H 6Z0I 8T51 8T59
Enriched GO Terms of Interacting Partners?		Regulation Of Cholesterol Transport Lipid Transport High-density Lipoprotein Particle Binding Low-density Lipoprotein Particle Binding Regulation Of Lipid Transport High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Regulation Of Phosphatidylcholine Catabolic Process Lipid Transporter Activity Sterol Transport Respiratory Burst After Phagocytosis Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Detection Of Lipopolysaccharide Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Regulation Of Phospholipid Catabolic Process Regulation Of Cholesterol Efflux Monoatomic Anion Channel Activity Positive Regulation Of Apoptotic Cell Clearance Respiratory Burst Involved In Defense Response Organophosphate Ester Transport Regulation Of Phosphatidylcholine Metabolic Process Regulation Of Apoptotic Cell Clearance Organic Hydroxy Compound Transport Cholesterol Transport Endoplasmic Reticulum Regulation Of Endocytosis Detection Of Molecule Of Bacterial Origin Phagocytosis, Recognition Kinase Activator Activity Regulation Of Lipid Metabolic Process Phosphatidylethanolamine Binding Regulation Of Transport Carbohydrate Derivative Transport Apolipoprotein Binding Ceramide Transport Positive Regulation Of Lipid Transport Membrane Phospholipid Transport Gap Junction Channel Activity Respiratory Burst Regulation Of Phagocytosis Gap Junction Plasma Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Efflux Cholesterol Metabolic Process Sterol Metabolic Process	Chylomicron Cellular Response To Amyloid-beta Response To Amyloid-beta Reverse Cholesterol Transport Cholesterol Transport Very-low-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Sterol Transport Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Cholesterol Efflux Lipoprotein Metabolic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling High-density Lipoprotein Particle Clearance Receptor Ligand Activity Spherical High-density Lipoprotein Particle Positive Regulation Of Endocytosis High-density Lipoprotein Particle Assembly Organic Hydroxy Compound Transport Phospholipid Efflux Low-density Lipoprotein Particle Low-density Lipoprotein Particle Remodeling Extracellular Space Endocytic Vesicle Lumen Sterol Homeostasis High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis High-density Lipoprotein Particle Chylomicron Remnant Positive Regulation Of Neurofibrillary Tangle Assembly Low-density Lipoprotein Particle Receptor Binding Cholesterol Metabolic Process Lipid Transport Regulation Of Endocytosis Phospholipid Binding Blood Microparticle Sterol Metabolic Process Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Signaling Receptor Binding Lipid Homeostasis Extracellular Region Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding
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