IRGM and TLR3

Number of citations of the paper that reports this interaction (PubMedID 32715615)
109

Data Source:
BioGRID (pull down)

		IRGM	TLR3
Description		immunity related GTPase M	toll like receptor 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Phagocytic Cup Mitochondrion Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Cell Projection	Golgi Membrane Cytoplasm Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Endosome Membrane Membrane Endolysosome Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Protein Serine/threonine Kinase Activator Activity CARD Domain Binding BH3 Domain Binding Cardiolipin Binding	RNA Binding Double-stranded RNA Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Autophagosome Assembly Positive Regulation Of Protein Phosphorylation Immune System Process Autophagy Inflammatory Response Lysosome Organization Positive Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Catabolic Process Protein Destabilization Negative Regulation Of Type I Interferon Production Negative Regulation Of Type II Interferon Production Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Defense Response To Bacterium Positive Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Protein Stabilization Defense Response To Gram-negative Bacterium Positive Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Protein Lipidation Involved In Autophagosome Assembly CAMKK-AMPK Signaling Cascade Protein-containing Complex Assembly Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Lipopolysaccharide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Mitochondrial Fission Autophagosome Maturation Cellular Response To Virus Antibacterial Innate Immune Response Negative Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Autophagosome Maturation Positive Regulation Of Mitophagy Positive Regulation Of Xenophagy Positive Regulation Of Lysosome Organization	MAPK Cascade Microglial Cell Activation Toll-like Receptor Signaling Pathway Immune System Process Positive Regulation Of Immune System Process Regulation Of Dendritic Cell Cytokine Production Defense Response Inflammatory Response Hyperosmotic Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Male Gonad Development Detection Of Virus Response To Virus Positive Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Type III Interferon Production Positive Regulation Of Type III Interferon Production Cellular Response To Interferon-beta Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Exogenous DsRNA Response To DsRNA Innate Immune Response Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Inflammatory Response Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cellular Response To Exogenous DsRNA Cellular Response To Xenobiotic Stimulus Inflammatory Response To Wounding Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Cellular Response To Virus Intracellular Signaling Cassette Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways			Trafficking and processing of endosomal TLR Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TLR3 deficiency - HSE UNC93B1 deficiency - HSE TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation RSV-host interactions
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17554261 17554300 18587394 21102463 28067908) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 23128233 28067908)	Autoimmune thyroid disease ( 32581359) Breast size ( 22747683) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		10 interacting genes: ATG10 ATG5 CGAS MAP1LC3C NLRP3 NOD1 NOD2 RIGI SH3GLB1 TLR3	13 interacting genes: CD14 CFTR CHEK2 CSK HLA-DRA IRGM MAP2K6 MYD88 RNF10 RNF216 TICAM1 TICAM2 TRAF6
Entrez ID		345611	7098
HPRD ID		19559	04324
Ensembl ID		ENSG00000237693	ENSG00000164342
Uniprot IDs		A1A4Y4	O15455
PDB IDs			1ZIW 2A0Z 2MK9 2MKA 3ULU 3ULV 5GS0 7C76 7WV3 7WV4 7WV5 7WVE 7WVF 7WVJ 8AR1 8YHT 8YHU 9LSH 9LSI 9LSJ
Enriched GO Terms of Interacting Partners?		Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Cytokine Production Involved In Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Pattern Recognition Receptor Activity Autophagy Positive Regulation Of Innate Immune Response Innate Immune Response Immune Response-activating Signaling Pathway Defense Response To Symbiont Positive Regulation Of Interleukin-8 Production Immune Response-regulating Signaling Pathway Defense Response To Other Organism Response To Stress Activation Of Immune Response Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Defense Response Cellular Response To Exogenous DsRNA Regulation Of Dendritic Cell Cytokine Production Intracellular Receptor Signaling Pathway Peptidoglycan Binding Positive Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Regulation Of Immune Response Cellular Response To DsRNA Positive Regulation Of Interleukin-6 Production Positive Regulation Of Immune Effector Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Other Organism Positive Regulation Of Immune Response Detection Of Biotic Stimulus Regulation Of Type I Interferon Production Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Interleukin-6 Production Response To Exogenous DsRNA Response To Virus Response To External Biotic Stimulus Macroautophagy Defense Response Detection Of Virus Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Autophagy	Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Immune Response Cell Surface Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Cellular Response To Lipopolysaccharide Regulation Of Immune Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Lipid Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Defense Response Endosome Membrane Toll-like Receptor Signaling Pathway Response To Lipopolysaccharide TRIF-dependent Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Immune System Process Signaling Adaptor Activity Positive Regulation Of Multicellular Organismal Process Intracellular Receptor Signaling Pathway Immune Response Response To Lipid Endolysosomal Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Lymphocyte Activation Innate Immune Response Regulation Of Cell Activation
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