ITM2A and SIT1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ITM2A	SIT1
Name		integral membrane protein 2A	signaling threshold regulating transmembrane adaptor 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Protein Binding	Protein Binding Kinase Binding SH2 Domain Binding
	Biological Process	Plasma Cell Differentiation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process	Adaptive Immune Response Immune System Process Signal Transduction T Cell Homeostasis Regulation Of T Cell Activation
GWAS		Birth weight ( 31043758 ) Graves' disease ( 23612905 ) Height ( 18391951 ) Nose size ( 27182965 ) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781 )	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065 )
Novel Interactors		None recorded	1 novel interactors: CDKN2A
Interacting Genes		7 interacting genes: CLDN7 FCGR1A FNDC9 MEOX2 SIT1 TMED9 TRIM14	17 interacting genes: APOL2 BMP10 CLRN2 CSK FYN GRB2 ITM2A LCK MALL PLN PTPN11 SYK TMBIM6 TMEM140 TSPAN33 UPK1B ZAP70
Entrez ID		9452	27240
HPRD ID		02200	05394
Ensembl ID		ENSG00000078596	ENSG00000137078
Uniprot IDs		O43736	Q9Y3P8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	T Cell Costimulation Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Leukocyte Activation Immune Response-activating Signaling Pathway Phospholipase Binding Cell Activation Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Activation Of Immune Response Beta Selection Cellular Developmental Process Cell Differentiation T Cell Receptor Signaling Pathway Lymphocyte Activation Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Localization Regulation Of Immune System Process T Cell Activation Protein Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Proliferation Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway CD4 Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Differentiation Regulation Of MAPK Cascade