CD86 and MARCH8

Number of citations of the paper that reports this interaction (PMID 12582153)
34

Data Source:
HPRD (in vitro, in vivo)

		CD86	MARCH8
Gene Name		CD86 molecule	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Lysosome Lysosomal Membrane Endosome Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Receptor Activity Receptor Binding Protein Binding Coreceptor Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity MHC Class II Protein Binding
	Biological Process	Response To Yeast Toll-like Receptor Signaling Pathway T Cell Proliferation Involved In Immune Response Negative Regulation Of T Cell Anergy Immune Response Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Aging Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Viral Process T Cell Costimulation Response To Interferon-gamma Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Lymphotoxin A Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Metal Ion Cellular Response To Cytokine Stimulus	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of MHC Class II Biosynthetic Process
Pathways		Signaling by the B Cell Receptor (BCR) Costimulation by the CD28 family Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CTLA4 inhibitory signaling CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CD28 dependent Vav1 pathway Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Antithymocyte globulin Abatacept Belatacept
Diseases
GWAS		Multiple sclerosis ( 22190364 21833088)	Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		6 interactors: CD28 CD80 CTLA4 ECE2 MARCH8 PARP1	5 interactors: CD86 IL1RAP UBE2D1 UBE2D3 UBE2H
Entrez ID		942	220972
HPRD ID		03011	17466
Ensembl ID		ENSG00000114013	ENSG00000165406
Uniprot IDs		A8K632 P42081	H0Y7C6 Q5T0T0
PDB IDs		1I85 1NCN	2D8S
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Interleukin-2 Production Immune System Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cytokine Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cytokine Biosynthetic Process Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Immune Response Regulation Of T Cell Differentiation Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Growth Rate Protein Poly-ADP-ribosylation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Adaptive Immune Response Positive Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Regulatory T Cell Differentiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T-helper 1 Cell Differentiation	Protein K48-linked Ubiquitination Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of Innate Immune Response Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Innate Immune Response Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Defense Response Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process BMP Signaling Pathway Toll-like Receptor 4 Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Positive Regulation Of Immune Response Negative Regulation Of T Cell Anergy Positive Regulation Of Lymphotoxin A Biosynthetic Process Cellular Response To Oxygen Levels Immune System Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Interleukin-4 Biosynthetic Process Cellular Macromolecule Catabolic Process Regulation Of Immune Response Transcription Initiation From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Organic Substance Response To Transforming Growth Factor Beta Interleukin-2 Biosynthetic Process DNA-templated Transcription, Initiation
Tagcloud ?		amixl atl bc blast burkitt cd54 cd58 cd80 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Difference) ?		amixl atl bc blast burkitt cd54 cd58 cd80 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Intersection) ?