DUSP14 and LMTK2

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		DUSP14	LMTK2
Description		dual specificity phosphatase 14	lemur tyrosine kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Early Endosome Golgi Apparatus Endomembrane System Membrane Growth Cone Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Myosin VI Binding Protein Serine Kinase Activity
	Biological Process		Receptor Recycling Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Endocytic Recycling Transferrin Transport Early Endosome To Late Endosome Transport Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Monocyte count ( 27863252 32888494) Ovarian cancer ( 23535730) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252) Red blood cell count ( 32888494)	Gamma glutamyl transferase levels ( 29403010 33339817) Hemoglobin levels ( 32327693) Prostate cancer ( 18264097) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		17 interacting genes: AATK CBY2 CD28 EPHA1 EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 IGF1R ISYNA1 LMTK2 PRMT5 PTK7 ROR1 ROR2 UCHL5	24 interacting genes: CDC14A CDC25C CDK5 CDK5R1 DUSP14 DUSP19 DUSP29 DUSP6 ILKAP MTMR6 PPM1A PPM1F PPM1K PPP1CA PPP1CB PPP1CC PPP1R2 PPP3CB PTPDC1 PTPN12 PTPN6 PTPRR STYX TPTE2
Entrez ID		11072	22853
HPRD ID		09427	13994
Ensembl ID		ENSG00000276023	ENSG00000164715
Uniprot IDs		O95147 Q6FI36	Q8IWU2
PDB IDs		2WGP
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ATP Binding Coreceptor Activity Enzyme-linked Receptor Protein Signaling Pathway Transferase Activity Nucleotide Binding Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction ERBB3:ERBB2 Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling ERBB2 Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Neuregulin Receptor Activity Protein Autophosphorylation Regulation Of ERK1 And ERK2 Cascade ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Growth Factor Binding Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Multicellular Organismal Development Animal Organ Development Mesenchyme Development Phosphorylation ERBB2-ERBB3 Signaling Pathway Glial Cell Development ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Lung-associated Mesenchyme Development Basal Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Wound Healing ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Ephrin Receptor Activity Heart Development	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Dephosphorylation Hydrolase Activity Cation Binding Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Phosphatase Activity PTW/PP1 Phosphatase Complex Protein Modification Process Glycogen Metabolic Process Cytoplasm Negative Regulation Of MAPK Cascade Peptidyl-tyrosine Dephosphorylation Energy Reserve Metabolic Process Polysaccharide Metabolic Process Entrainment Of Circadian Clock By Photoperiod Protein Kinase 5 Complex Photoperiodism Entrainment Of Circadian Clock Cytosol MAPK Cascade Rhythmic Process Cell Division Protein Kinase Binding Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Circadian Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Nucleoplasm Protein Metabolic Process Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Phosphatase Activity Layer Formation In Cerebral Cortex Negative Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm Protein Phosphatase 1 Binding Positive Regulation Of Protein Targeting To Membrane Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of Signaling Regulation Of Establishment Of Protein Localization
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