DUSP14 and ROR2

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		DUSP14	ROR2
Description		dual specificity phosphatase 14	receptor tyrosine kinase like orphan receptor 2
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GO Annotations	Cellular Component	Cytoplasm	Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Receptor Complex
	Molecular Function	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding
	Biological Process		Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Cell Migration
Pathways			PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases			Robinow syndrome Brachydactyly, including: type A; type B; type D; type E
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Monocyte count ( 27863252 32888494) Ovarian cancer ( 23535730) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252) Red blood cell count ( 32888494)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)
Interacting Genes		17 interacting genes: AATK CBY2 CD28 EPHA1 EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 IGF1R ISYNA1 LMTK2 PRMT5 PTK7 ROR1 ROR2 UCHL5	73 interacting genes: ACTMAP ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C1orf94 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR23E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34
Entrez ID		11072	4920
HPRD ID		09427	03822
Ensembl ID		ENSG00000276023	ENSG00000169071
Uniprot IDs		O95147 Q6FI36	Q01974
PDB IDs		2WGP	3ZZW 4GT4 6OSH 6OSN 6OSV 9FSE
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ATP Binding Coreceptor Activity Enzyme-linked Receptor Protein Signaling Pathway Transferase Activity Nucleotide Binding Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction ERBB3:ERBB2 Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling ERBB2 Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Neuregulin Receptor Activity Protein Autophosphorylation Regulation Of ERK1 And ERK2 Cascade ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Growth Factor Binding Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Multicellular Organismal Development Animal Organ Development Mesenchyme Development Phosphorylation ERBB2-ERBB3 Signaling Pathway Glial Cell Development ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Lung-associated Mesenchyme Development Basal Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Wound Healing ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Ephrin Receptor Activity Heart Development	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphate-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cation Binding Calmodulin-dependent Protein Phosphatase Activity Regulation Of Phosphatidylinositol Dephosphorylation Intracellular Signaling Cassette Phosphatidylinositol Dephosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Peptidyl-threonine Dephosphorylation MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Phospholipid Dephosphorylation Positive Regulation Of Biosynthetic Process Phosphatidylinositol-3-phosphate Phosphatase Activity Positive Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Linear Polyubiquitin Binding Regulation Of Metabolic Process N-terminal Protein Myristoylation Protein Serine/threonine Kinase Binding Regulation Of DNA-templated Transcription Regulation Of Dephosphorylation Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Neuron Differentiation Negative Regulation Of Signaling Receptor Tyrosine Kinase Binding Protein Binding Regulation Of Protein Serine/threonine Kinase Activity Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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