DUSP14 and EPHA1

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		DUSP14	EPHA1
Description		dual specificity phosphatase 14	EPH receptor A1
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GO Annotations	Cellular Component	Cytoplasm	Plasma Membrane Membrane Receptor Complex
	Molecular Function	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	Nucleotide Binding Fibronectin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding
	Biological Process		Angiogenesis Positive Regulation Of Cell-matrix Adhesion Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Monocyte count ( 27863252 32888494) Ovarian cancer ( 23535730) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252) Red blood cell count ( 32888494)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) Family history of Alzheimer's disease ( 30617256) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		17 interacting genes: AATK CBY2 CD28 EPHA1 EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 IGF1R ISYNA1 LMTK2 PRMT5 PTK7 ROR1 ROR2 UCHL5	12 interacting genes: CTDSP2 DAPK1 DUSP14 EFNA1 ERBB2 GJB1 MAP3K1 MTMR14 PTPN11 SMURF1 SMURF2 TPTE
Entrez ID		11072	2041
HPRD ID		09427	01554
Ensembl ID		ENSG00000276023	ENSG00000146904
Uniprot IDs		O95147 Q6FI36	P21709
PDB IDs		2WGP	2K1K 2K1L 3HIL 3KKA
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ATP Binding Coreceptor Activity Enzyme-linked Receptor Protein Signaling Pathway Transferase Activity Nucleotide Binding Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction ERBB3:ERBB2 Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling ERBB2 Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Neuregulin Receptor Activity Protein Autophosphorylation Regulation Of ERK1 And ERK2 Cascade ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Growth Factor Binding Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Multicellular Organismal Development Animal Organ Development Mesenchyme Development Phosphorylation ERBB2-ERBB3 Signaling Pathway Glial Cell Development ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Lung-associated Mesenchyme Development Basal Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Wound Healing ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Ephrin Receptor Activity Heart Development	Protein Modification Process Phosphoprotein Phosphatase Activity Phosphate-containing Compound Metabolic Process Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Cell Surface Receptor Signaling Pathway Protein Metabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Ephrin Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Engulfment Of Target By Autophagosome SMAD Binding Non-canonical Wnt Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Negative Regulation Of T Cell Proliferation ERBB3:ERBB2 Complex ERBB Signaling Pathway Cellular Response To Mechanical Stimulus Intestinal Epithelial Cell Migration Phosphatase Activity Protein Phosphorylation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Phosphorylation Notochord Formation RNA Polymerase I Core Binding Cerebellar Cortex Formation Negative Regulation Of Leukocyte Proliferation Signal Transduction Regulation Of NMDA Receptor Activity Positive Regulation Of MAPK Cascade Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Immature T Cell Proliferation In Thymus Glial Cell Differentiation ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus
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