CD27 and CCND2

Data Source: HiPPIP (Novel)

		CD27	CCND2
Name		CD27 molecule	cyclin D2
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Membrane Nuclear Membrane Cyclin D2-CDK4 Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response T Cell Activation Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Adaptive Immune Memory Response Involving T Cells And B Cells Extrinsic Apoptotic Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	G1/S Transition Of Mitotic Cell Cycle Long-term Memory Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Apoptotic Process Cell Division Regulation Of Cell Cycle Cellular Response To X-ray Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		TNFs bind their physiological receptors	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity
Diseases		None	Testicular cancer
GWAS		Crohn's disease ( 26192919 )	Alanine aminotransferase levels ( 34315874 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 34315874 ) Birth weight ( 31043758 ) Blond vs. brown/black hair color ( 30531825 ) Blood glucose levels ( 31928498 ) Brown vs. black hair color ( 30531825 ) Colorectal cancer ( 24836286 31826910 26151821 30529582 23266556 23263487 ) Colorectal cancer or advanced adenoma ( 30510241 ) Glucocorticoid-induced osteonecrosis ( 26265699 ) Height ( 28270201 28552196 ) Low density lipoprotein cholesterol levels ( 32154731 ) Major depressive disorder ( 19107115 23377640 ) Mean corpuscular hemoglobin ( 28017375 ) Mean corpuscular volume ( 28017375 ) Obesity-related traits ( 23251661 ) Offspring birth weight ( 31043758 ) Pulse pressure ( 27841878 30578418 ) QT interval (drug interaction) ( 23459443 ) Red blood cell count ( 20139978 28017375 ) Red blood cell traits ( 23222517 ) Smoking behaviour (cigarettes smoked per day) ( 30679032 ) Triglyceride levels ( 31928498 32154731 32203549 ) Type 2 diabetes ( 30297969 31118516 30054458 29358691 28869590 32499647 22885922 ) Waist circumference ( 31928498 )
Novel Interactors		6 novel interactors: CCND2 CHD4 CREBL2 ELF1 ENO2 ETV6	3 novel interactors: ARID5B CD27 MAD1L1
Interacting Genes		8 interacting genes: ACTN2 CD70 CIB1 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2	64 interacting genes: ABCB5 ABL1 ADRB2 AKAP8 AKT1 ARAF ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2
Entrez ID		939	894
HPRD ID		01723	00451
Ensembl ID		ENSG00000139193	ENSG00000118971
Uniprot IDs		P26842	P30279
PDB IDs		5TL5 5TLJ 5TLK 7KX0 8DS5	6EI2
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway CD27 Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Apoptotic Process Regulation Of RNA Metabolic Process Cell Death Programmed Cell Death Cytoplasmic Side Of Plasma Membrane Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Apoptotic Process Metal Ion Binding Regulation Of Programmed Cell Death Regulation Of Gene Expression Actin Filament Uncapping Positive Regulation Of Protein Phosphorylation TORC2 Complex Disassembly Positive Regulation Of Male Germ Cell Proliferation CD27 Receptor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune System Process Positive Regulation Of Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Ubiquitin-protein Transferase Activity Regulation Of Primary Metabolic Process Chromatin MRNA Stabilization Protein Autoubiquitination Titin Z Domain Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly	Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Signal Transduction Protein Kinase Activity Regulation Of Cell Cycle Process Regulation Of Cell Population Proliferation Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase Binding Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Developmental Process Positive Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of Growth Regulation Of Apoptotic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Cellular Senescence Regulation Of Catalytic Activity Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Developmental Process Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Programmed Cell Death Cell Death Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Cell Differentiation Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cell Differentiation